Critical roles of co‐activation receptor DNAX accessory molecule‐1 in natural killer cell immunity
Critical roles of co‐activation receptor DNAX accessory molecule‐1 in natural killer cell immunity
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DOI：
10.1111/imm.12516
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发表时间：
2015-11
期刊：
影响因子：
6.4
通讯作者：
P. Xiong;Hai-wei Sang;Min Zhu
中科院分区：
文献类型：
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作者：
P. Xiong;Hai-wei Sang;Min Zhu
Natural killer (NK) cells, which can exert early and powerful anti‐tumour and anti‐viral responses, are important components of the innate immune system. DNAX accessory molecule‐1 (DNAM‐1) is an activating receptor molecule expressed on the surface of NK cells. Recent findings suggest that DNAM‐1 is a critical regulator of NK cell biology. DNAM‐1 is involved in NK cell education and differentiation, and also plays a pivotal role in the development of cancer, viral infections and immune‐related diseases. However, tumours and viruses have developed multiple mechanisms to evade the immune system. They are able to impair DNAM‐1 activity by targeting the DNAM‐1 receptor–ligand system. We have reviewed the roles of DNAM‐1, and its biological functions, with respect to NK cell biology and DNAM‐1 chimeric antigen receptor‐based immunotherapy.
