Primary mesenchymal tumors of the pancreas in a single center over 15 years
Primary mesenchymal tumors of the pancreas in a single center over 15 years
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超过 15 年的单中心胰腺原发性间叶质肿瘤。
DOI：
10.3892/ol.2016.5155
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发表时间：
2016-11-01
期刊：
影响因子：
2.9
通讯作者：
Chen, Jie
中科院分区：
文献类型：
--
作者：
Zhang, Hongkai;Yu, Shuangni;Chen, Jie
总的来说，95%的胰腺原发性肿瘤是上皮性肿瘤;在这个部位的原发性间叶肿瘤非常罕见。目前，只有一个关于这些罕见肿瘤的综合研究已经完成。本研究对这些罕见肿瘤进行了另一项回顾性分析，据我们所知，这是在中国首次进行的。本研究收集了中国医学科学院和北京协和医学院近15年来收治的10例胰腺原发性间叶肿瘤患者，占同期手术切除胰腺原发性肿瘤的0.51%。10例患者中，7例（70%）诊断为良性/交界性肿瘤，其余3例（30%）诊断为恶性肿瘤。本研究的一个独特发现是，术前诊断经常被误诊，就具体的病理诊断而言。因此，虽然胰腺原发性间叶细胞肿瘤非常罕见，但为了做出正确的术前诊断，应考虑到它们。与以前的研究不同，在本研究中，最常见的良性肿瘤不是硬纤维瘤，而是孤立性纤维瘤;最常见的原发性肉瘤也不是未分化/未分类的肉瘤。总之，本研究有助于了解这些罕见的肿瘤，但是，胰腺原发性间叶肿瘤需要在未来进行额外的探索。
In total, 95% of primary tumors in the pancreas are epithelial tumors; primary mesenchymal tumors at this site are extremely rare. At present, only one comprehensive study about these rare tumors has been performed. Another retrospective analysis of these rare tumors is performed in the present study, which, to the best of our knowledge, is the first to be performed in China. In the present study, 10 patients that underwent resection for primary mesenchymal tumors of the pancreas were identified in a 15-year period at the Chinese Academy of Medical Sciences and Peking Union Medical College, which accounted for 0.51% of the total surgically resected primary tumors of the pancreas at this hospital. Among the 10 patients, 7 patients (70%) were diagnosed with benign/borderline tumors, and the remaining 3 patients (30%) were diagnosed with malignant tumors. It was a unique finding of the present study that the preoperative diagnosis was frequently a misdiagnosis, in terms of the specific pathological diagnosis. Therefore, although primary mesenchymal tumors of the pancreas are extremely rare, they should be considered in order to make the correct preoperative diagnosis. Contrarily to a previous study, in the present study, the most common benign tumor was not desmoid tumor, but solitary fibrous tumors; the most frequent primary sarcoma was not undifferentiated/unclassified sarcoma either. In conclusion, the present study aids the understanding of these rare tumors; however, primary mesenchymal tumors of the pancreas require additional exploration in the future.