Role of B-cell receptors for B-cell development and antigen-induced differentiation.
Role of B-cell receptors for B-cell development and antigen-induced differentiation.
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DOI：
10.12688/f1000research.13567.1
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Toellner KM
中科院分区：
文献类型：
--
作者：
Yam-Puc JC;Zhang L;Zhang Y;Toellner KM
B细胞发育的特征在于许多严格调控的选择过程。通过B细胞受体（BCR）引导的信号是B细胞成熟、存活和命运决定所必需的。在此，我们回顾了BCR在B细胞发育过程中的作用，导致B1、边缘区和外周滤泡B细胞的出现。此外，我们讨论了BCR衍生的信号激活B细胞，导致生发中心和浆细胞分化。
B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.