Hydrogen is neuroprotective against surgically induced brain injury.
Hydrogen is neuroprotective against surgically induced brain injury.
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DOI：
10.1186/2045-9912-1-7
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发表时间：
2011-05-18
影响因子：
2.9
通讯作者：
Zhang JH
中科院分区：
文献类型：
--
作者：
Eckermann JM;Chen W;Jadhav V;Hsu FP;Colohan AR;Tang J;Zhang JH
神经外科手术对健康的脑组织造成不可避免的损害。直接手术损伤以及手术诱导的氧化应激有助于随后形成脑水肿。因此，我们测试了氢（H2）的神经保护作用，在一个建立的外科脑损伤（SBI）模型的大鼠。将成年雄性Sprague -道利大鼠（体重300- 350 g）分为三组，作为假手术组、SBI未处理组和SBI用H2（2.9%）处理组。于SBI后24小时测定脑含水量、髓过氧化物酶（MPO）、脂质过氧化反应（LPO）和神经功能。SBI导致局部脑水肿（p = < 0.001）。手术同时给予氢（2.9%）显著减少了脑水肿的形成（p = 0.028），并改善了神经行为评分（p = 0.022）。然而，氢处理未能减少脑组织中的氧化应激（LPO测定）或炎症（MPO测定）。氢气似乎是一种有效而廉价的方法，可以减少手术引起的脑水肿。氢气有可能改善临床结果，减少住院时间，并降低患者和医疗保健系统的总体成本。
Neurosurgical operations cause unavoidable damage to healthy brain tissues. Direct surgical injury as well as surgically induced oxidative stress contributes to the subsequent formation of brain edema. Therefore, we tested the neuroprotective effects of hydrogen (H2) in an established surgical brain injury (SBI) model in rats. Adult male Sprague - Dawley rats (weight 300-350g) were divided into three groups to serve as sham operated, SBI without treatment, and SBI treated with H2 (2.9%). Brain water content, myeloperoxidase (MPO) assay, lipid peroxidation (LPO), and neurological function were measured at 24 hrs after SBI. SBI resulted in localized brain edema (p = < 0.001). Hydrogen (2.9%) administered concurrently with surgery significantly decreased the formation of cerebral edema (p = 0.028) and improved neurobehavioral score (p = 0.022). However, hydrogen treatment failed to reduce oxidative stress (LPO assay) or inflammation (MPO assay) in brain tissues. Hydrogen appears to be promising as an effective, yet inexpensive way to reduce cerebral edema caused by surgical procedures. Hydrogen has the potential to improve clinical outcome, decrease hospital stay, and reduce overall cost to patients and the health care system.