Area-specific representation of mechanical nociceptive stimuli within SI cortex of squirrel monkeys.
Area-specific representation of mechanical nociceptive stimuli within SI cortex of squirrel monkeys.
复制标题
DOI：
10.1016/j.pain.2008.11.018
复制
发表时间：
2009-02
期刊：
影响因子：
7.4
通讯作者：
Roe AW
中科院分区：
文献类型：
--
作者：
Chen LM;Friedman RM;Roe AW
虽然人类功能成像研究一直报道疼痛刺激会激活初级躯体感觉皮质（SI），但SI内区域3a、3b和1的细分在疼痛感知期间的具体作用在很大程度上尚不清楚，特别是在机械诱发疼痛的表现方面。在这项研究中，我们研究了如何模态，位置和伤害性刺激的强度内SI表示使用高空间分辨率的光学成像的内在信号在Pentothal-anesthesized松鼠猴。知觉可比的机械伤害性和无害的触觉刺激，通过用0.2和2 mm直径的探针分别对远端指垫的无毛皮肤进行压痕来提供。在区域3a、3b和1中的每一个内，对各个远端指垫的机械伤害性刺激的激活在空间上不同并且在躯体位置上组织。我们观察到不同的皮层激活模式。3a、3b和1区在机械伤害性刺激时均被激活，并受伤害性刺激强度的调节。然而，在无害的触觉刺激下，主要是3b区和1区在不同刺激水平下表现出反应调制。总之，机械伤害性输入是区域特异性的，并且在SI内以地形图表示。我们认为SI的所有区域都参与编码机械伤害性感受的特征，其中区域3a和3b特别参与编码刺激的伤害性感受和压力感觉成分。
While functional imaging studies in humans have consistently reported activation of primary somatosensory cortex (SI) with painful stimuli, the specific roles of subdivisions of areas 3a, 3b and 1 within SI during pain perception are largely unknown, particularly in the representation of mechanical evoked pain. In this study, we investigated how modality, location, and intensity of nociceptive stimuli are represented within SI by using high-spatial resolution optical imaging of intrinsic signals in Pentothal-anesthetized squirrel monkeys. Perceptually comparable mechanical nociceptive and innocuous tactile stimuli were delivered by indenting the glabrous skin of the distal fingerpads with 0.2 and 2 mm diameter probes, respectively. Within each of areas 3a, 3b, and 1, activations to mechanical nociceptive stimulation of individual distal fingerpads were spatially distinct and somatotopically organized. We observed differential cortical activation patterns. Areas 3a, 3b and 1 were all activated during mechanical nociceptive stimulation and were modulated by nociceptive stimulus intensity. However, with innocuous tactile stimulation, mainly areas 3b and 1 exhibited response modulation with different levels of stimulation. In summary, mechanical nociceptive inputs are area-specific and topographically represented within SI. We propose that all areas of SI are implicated in encoding the features of mechanical nociception, where areas 3a and 3b are distinctively involved in coding nociceptive and pressure sensation components of stimulation.
登录
查看更多内容
影响因子：
3.5
作者：
BRESLIN, PAS;GILMORE, MM;GREEN, BG
通讯作者：
GREEN, BG
影响因子：
2.5
作者：
Friedman, Robert M.;Chen, Li Min;Roe, Anna W.
通讯作者：
Roe, Anna W.
影响因子：
0.9
作者：
Greenspan, JD;Thomadaki, M;McGillis, SLB
通讯作者：
McGillis, SLB
影响因子：
56.9
作者：
CASEY, KL;MORROW, TJ
通讯作者：
MORROW, TJ
DOI：
10.1073/pnas.96.14.7705
发表时间：
1999-07-06
影响因子：
11.1
作者：
Bushnell, MC;Duncan, GH;Carrier, B
通讯作者：
Carrier, B