Measurement of erythropoietin in anephric children. A report of the Southwest Pediatric Nephrology Study Group.
Measurement of erythropoietin in anephric children. A report of the Southwest Pediatric Nephrology Study Group.
复制标题
无肾儿童促红细胞生成素的测量。
DOI：
10.1007/bf00859630
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Fisher,JW
中科院分区：
文献类型：
--
作者：
Beckman,BS;Brookins,JW;Garcia,MM;Fisher,JW
Serum erythropoietin (Ep) levels were measured using a highly sensitive radioimmunoassay in 69 children undergoing chronic dialysis; 31 were anephric, whereas 38 were non-nephrectomized (nephric). Twenty-nine normal children were studied as controls. Serum Ep levels in the anephric group were much higher than anticipated (mean 19.7±1.8 mU/ml), albeit significantly lower than those measured in normal children (mean 26.2±2.4 mU/ml,P<0.05), or in nephric children on dialysis (33.0±2.9 mU/ml,P<0.001). Anephric children on peritoneal dialysis (PD) had significantly (P<0.05) higher serum levels of Ep (22.7±2.4 mU/ml,n=19) than anephric children on hemodialysis (HD) (15.1±2.3 mU/ml,n=12). There was no significant difference between Ep levels in anephric patients dialyzed for less than or equal to 1 year (19.6±2.0 mU/ml,n=20) compared with anephric patients dialyzed for more than 1 year (20.0±3.9 mU/ml,n=11). Although serum Ep levels showed a tendency to increase with time after nephrectomy, the mean values for <3 months (14.7±1.9), 3 months–12 months (21.0±2.7), and >12 months (21.6±6.0) were not significantly different from each other. This demonstration of relatively normal levels of serum Ep in anephric children suggests that extrarenal sites of Ep production are able to exert a significant response to severe anemia in patients who are devoid of renal parenchyma.
