TUDOR, A GENE REQUIRED FOR ASSEMBLY OF THE GERM PLASM IN DROSOPHILA-MELANOGASTER
TUDOR, A GENE REQUIRED FOR ASSEMBLY OF THE GERM PLASM IN DROSOPHILA-MELANOGASTER
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DOI：
10.1016/0092-8674(85)90015-7
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发表时间：
1985-01-01
期刊：
影响因子：
64.5
通讯作者：
MAHOWALD, AP
中科院分区：
文献类型：
--
作者：
BOSWELL, RE;MAHOWALD, AP
一个新分离的母体效应无孙突变体，都铎（tud），在果蝇的发育分析表明，tud+活性需要在卵子发生过程中的确定和/或形成的原始生殖细胞（极细胞）和正常的胚胎腹部分割。无论其基因型，后代的女性纯合的强等位基因（tud 1和tud 3）从来没有形成极细胞，显然缺乏极颗粒的种质，约40%的人死在胚胎发育后期表现出严重的腹部分割模式缺陷。携带弱等位基因tud 4的雌性产生具有一些功能性极细胞的后代，并形成约为野生型卵母细胞和胚胎中观察到的极性颗粒大小的三分之一的极性颗粒。在来自tud 4/tud 4雌性的不存活胚胎中未观察到分割异常。
Developmental analysis of a newly isolated maternal effect grandchildless mutant, tudor (tud), in Drosophila melanogaster indicates that tud+ activity is required during oogenesis for the determination and/or formation of primordial germ cells (pole cells) and for normal embryonic abdominal segmentation. Regardless of their genotype, progeny of females homozygous for strong alleles (tud1 and tud3) never form pole cells, apparently lack polar granules in the germ plasm, and approximately 40% of them die during late embryogenesis exhibiting severe abdominal segmentation pattern defects. Females carrying weak allele, tud4, produce progeny with some functional pole cells and form polar granules approximately one-third the size of those observed in wild-type oocytes and embryos. No segmentation abnormalities are observed in the inviable embryos derived from tud4/tud4 females.