In the Lyme light: individual trait determinants of Borrelia burgdorferi infection in Peromyscus mice

In the Lyme light: individual trait determinants of Borrelia burgdorferi infection in Peromyscus mice
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在莱姆病中:白腹鼠伯氏疏螺旋体感染的个体性状决定因素

DOI:
10.1093/jmammal/gyad108
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发表时间:
2023
影响因子:
1.7
通讯作者:
Mortelliti, Alessio
Mortelliti, Alessio
中科院分区:
生物学3区
文献类型:
--
作者:
Yen, Ivy;Gardner, Allison;Mortelliti, Alessio

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疾病生态学家通常使用非生物因素(例如温度和湿度)或生物多样性(例如物种丰富度)来预测莱姆病的传播模式,但对人群中个体之间感染概率的差异知之甚少。大多数研究假设种内一致性,但最近的证据表明,个体特征,如动物的个性,可能会通过不同的空间使用和微生境选择,导致感染概率的种内变异,从而导致感染率的差异与感染的载体和病原体传播概率的遭遇率。此外,由于病媒和宿主是非随机分布在整个景观,土地利用的变化,修改关键的栖息地功能,如森林管理的做法,可能会大大改变个人特征和感染概率之间的关联。为了解决我们知识中的这些空白,我们使用了一个大规模的捕获标记再捕获研究,目标是美国缅因州的Peromyscus小鼠,以测试是否个性驱动的概率伯氏疏螺旋体感染的主机内管理的森林隔间与不同的造林治疗。具体而言,我们测试了个体表型性状(物理和行为)和环境性状(微生境和森林类型)对2个物种感染概率的影响:白对虾和白对虾。有毛的。我们发现的证据表明,大胆的负面影响感染概率在P。maniculatus,和身体质量积极影响感染概率在这两个物种。在我们的分析中,我们没有发现小鼠密度、微生境或森林类型的影响。这些结果表明,不同的个性在他们的功能性贡献的自然循环的B。burgdorferi,并在疾病生态学研究中更广泛地整合行为多样性,可能有助于确定这种迅速扩大的病媒传播的人畜共患病的关键传播区。
Disease ecologists commonly use abiotic factors (e.g. temperature and moisture) or measures of biodiversity (e.g. species richness) to predict Lyme disease transmission patterns, but variance in infection probability among individuals within a population is poorly understood. Most studies assume intraspecific consistency, but recent evidence suggests that individual traits, such as animal personality, may drive differences in encounter rates with infected vectors and pathogen transmission probabilities through differential space use and microhabitat selection, leading to intraspecific variation in infection probability. In addition, because vectors and hosts are nonrandomly distributed across a landscape, land-use changes that modify key habitat features—such as forest management practices—may substantially alter associations between individual traits and infection probability. To address these gaps in our knowledge, we used a large-scale capture–mark–recapture study targetingPeromyscusmice in Maine, United States, to test whether personality drives probability ofBorrelia burgdorferiinfection in hosts within managed forest compartments with different silvicultural treatments. Specifically, we tested effects of individual phenotypic traits (physical and behavioral) and environmental traits (microhabitat and forest type) on infection probability within 2 species:P. leucopusandP. maniculatus. We found evidence that boldness negatively influences infection probability inP. maniculatus, and that body mass positively influences infection probability in both species. We found no effect of mouse density, microhabitat, or forest type in our analyses. These results suggest that personalities vary in their functional contributions to the natural cycle ofB. burgdorferi, and that broader integration of behavioral diversity in disease ecology studies may aid in identifying key transmission zones for this rapidly expanding vector-borne zoonosis.
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