Severe acute respiratory syndrome (SARS) in a liver transplant recipient and guidelines for donor SARS screening
Severe acute respiratory syndrome (SARS) in a liver transplant recipient and guidelines for donor SARS screening
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DOI：
10.1034/j.1600-6143.2003.00197.x
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发表时间：
2003-08-01
影响因子：
8.8
通讯作者：
Humar, A
中科院分区：
文献类型：
--
作者：
Kumar, D;Tellier, R;Humar, A
严重急性呼吸系统综合征（SARS）是一种新近发现的以发热、头痛和不适为主要特征的传染性疾病，并可迅速发展为肺炎。SARS的病原可能是一种新型冠状病毒。2003年冬季，加拿大多伦多发生了一场涉及多家医院的SARS疫情。我们描述了一位肝移植后感染SARS并在疫情爆发期间死亡的患者，随后感染了家人和几名医护人员。通过PCR方法在呼吸道标本中检测到一种新型冠状病毒。由于SARS在移植受者中的潜在严重性以及社区中大量的SARS病例，为了避免SARS从捐赠者传播，我们制定了器官捐赠者SARS筛查指南。根据潜在的医院SARS暴露，临床症状和流行病学暴露的筛选工具，用于分层捐助者为高，中，低风险的SARS。随着SARS在全世界的传播，它可能成为移植患者和移植项目的一个日益严重的问题。
Severe acute respiratory syndrome (SARS) is a recently described infectious entity with salient features of fever, headache and malaise, with rapid progression to pneumonitis. The etiology of SARS is likely a novel coronavirus. During the winter of 2003, an outbreak of SARS involving several hospitals occurred in Toronto, Canada. We describe a patient post liver transplant who contracted SARS and died during the outbreak, with subsequent infection of family and several health-care workers. A novel coronavirus was detected in respiratory specimens by PCR. Due to the potential severity of SARS in transplant recipients and the large number of cases of SARS in the community, in order to avoid transmission of SARS from a donor, we developed guidelines for SARS screening of organ donors. A screening tool based on potential hospital SARS exposure, clinical symptoms, and epidemiological exposure was used to stratify donors as high, intermediate or low risk for SARS. As SARS spreads throughout the world, it may become an increasingly significant problem for transplant patients and programs.