Diffuse luminance flicker increases retinal vessel diameter in humans
Diffuse luminance flicker increases retinal vessel diameter in humans
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DOI：
10.1076/ceyr.16.12.1252.5021
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发表时间：
1997-12-01
影响因子：
2
通讯作者：
Geiser, M
中科院分区：
文献类型：
--
作者：
Formaz, F;Riva, CE;Geiser, M
目的.确定视网膜血管直径对漫反射亮度闪烁诱导的神经元活动的反应变化。方法。本文应用计算机分析了9例正常人在正常照明条件下用单色光拍摄的眼底图像，以及在10 Hz下用正弦变化的漫射亮度闪烁1 min后的眼底图像，测量了视网膜动脉和静脉的直径。闪烁后即刻的视网膜动脉直径显著大于刺激前直径4.2 +/- 2.2%，视网膜静脉直径显著大于刺激前直径2.7 +/- 1.7%（平均值+/- SD）。闪烁停止后6 s，动脉直径与闪烁前无显著差异。漫射亮度闪烁引起视网膜血管直径增加。这种增加很可能反映了先前通过蓝场模拟技术在人类中证明的视网膜血流量的增加。该技术需要在闪烁参数方面进行优化，以确定闪烁诱发的视网膜直径变化是否可以代表视网膜血管系统血管舒张能力的有用临床测量。
Purpose. To determine retinal vessel diameter variations in response to neuronal activity induced by diffuse luminance flicker.Methods. The diameter of retinal arteries and veins was measured in 9 normal subjects by computer analysis of fundus pictures taken in monochromatic light under normal conditions of illumination and after 1 min of sinusoidally varying diffuse luminance flicker at 10 Hz.Results. The diameter immediately after flicker was significantly larger than the pre-stimulus diameter by 4.2 +/- 2.2% for the retinal arteries and 2.7 +/- 1.7% for the retinal veins (mean +/- SD). Six s after cessation of the flicker, arterial diameter was not significantly different from that of pre-flicker value.Conclusions. Diffuse luminance flicker induces an increase in retinal vessel diameter. This increase most probably reflects an increase in retinal blood flow previously evidenced in humans by the blue field simulation technique. The technique needs to be optimized in terms of flicker parameters, to determine whether flicker-evoked retinal diameter changes could represent a useful clinical measure of the capability of the retinal vascular system to vasodilate.