Comparison of immunogenicity of a whole virion and a subunit influenza vaccine in adults
Comparison of immunogenicity of a whole virion and a subunit influenza vaccine in adults
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全病毒颗粒和亚单位流感疫苗在成人中的免疫原性比较
DOI：
10.1128/jcm.8.4.431-434.1978
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发表时间：
1978
影响因子：
9.4
通讯作者：
H. Liebhaber
中科院分区：
文献类型：
--
作者：
D. Ortbals;H. Liebhaber
在一组214名正常成人受试者中比较了全病毒（Merck Sharp & Dohme）和亚单位（Wyeth）A/新泽西/76流感疫苗的免疫原性和反应原性。接种亚单位疫苗的受者的血清阳转率和血凝抑制抗体应答强度均显著低于对照组（P <0.01），而两种疫苗的局部或全身反应无显著差异。根据这些数据，我们对公共卫生服务部先前的建议提出质疑，即一剂A/新泽西/76流感疫苗制剂对24岁以上的个体同样有效。
The immunogenicity and reactogenicity of a whole virus (Merck Sharp & Dohme) and a subunit (Wyeth) influenza A/New Jersey/76 vaccine were compared in a group of 214 normal adult subjects. Both the seroconversion rate and the magnitutde of hemagglutination inhibition antibody response were significantly (P less than 0.01) lower in the recipients of the subunit vaccine, whereas there were no significant differences in local or systemic reactions between the two preparations. On the basis of these data, we question the previous Public Health Service recommendation that one dose of either preparation of the influenza A/New Jersey/76 vaccine is equally efficacious in individuals over 24 years of age.