Brain response to viewing others being harmed in children with conduct disorder symptoms.
Brain response to viewing others being harmed in children with conduct disorder symptoms.
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DOI：
10.1111/jcpp.12474
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Decety J
中科院分区：
文献类型：
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作者：
Michalska KJ;Zeffiro TA;Decety J
缺乏移情处理被认为是促进行为障碍（CD）。重要的是要确定与感知对他人的伤害相关的神经反应在多大程度上预测CD症状和对他人的冷漠。从儿科和心理健康诊所共招募了107名9-11岁儿童（52名女性），代表了广泛的CD症状。孩子们在观看有意或无意伤害的简短视频剪辑时进行功能性磁共振成像扫描。在所有参与者中，感知伤害引起前额叶（aINS）、前扣带皮层（ACC）、杏仁核、导水管周围灰质（PAG）、尾状核和下顶叶（IPL）的血流动力学反应增加。相对于无意伤害，故意造成的伤害与aINS、杏仁核和颞极的更大活动相关。在伤害>无伤害和有意>无意伤害对比中，CD症状数量与右后鼻孔呈负相关。此外，在伤害>无伤害对比中发现冷酷无情和后额叶激活之间的负相关，反应性攻击得分的模式相反。在故意伤害与非故意伤害对比中，交互作用显示女孩CD症状与右后上级颞沟（pSTS）之间的关联更强。患有严重CD和冷酷无情的儿童在看到他人受到伤害时表现出血流动力学反应减弱，这是一个在同情和情绪意识中起关键作用的区域。性别差异的神经相关的CD进行了观察。
Deficient empathic processing is thought to foster conduct disorder (CD). It is important to determine the extent to which neural response associated with perceiving harm to others predicts CD symptoms and callous disregard for others. A total of 107 9-11 year old children (52 female) were recruited from pediatric and mental health clinics, representing a wide range of CD symptoms. Children were scanned with functional magnetic resonance imaging while viewing brief video clips of persons being harmed intentionally or accidentally. Perceiving harm evoked increased hemodynamic response in the anterior insula (aINS), anterior cingulate cortex (ACC), amygdala, periaqueductal gray (PAG), caudate, and inferior parietal lobe (IPL) across all participants. Intentionally-caused, relative to unintentional harm was associated with greater activity in the aINS, amygdala, and temporal pole. There was an inverse association of number of CD symptoms with right posterior insula in both the Harm > No Harm and the Intentional > Unintentional Harm contrasts. Furthermore, an inverse association between callousness and posterior insula activation was found in the Harm > No Harm contrast, with the opposite pattern for reactive aggression scores. An interaction revealed a stronger association in girls between CD symptoms and the right posterior superior temporal sulcus (pSTS) in the Intentional Harm vs. Unintentional Harm contrast. Children with greater CD and callousness exhibit dampened hemodynamic response to viewing others being harmed in the insula, a region which plays a key role in empathy and emotional awareness. Sex differences in the neural correlates of CD were observed.