NCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings.
NCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings.
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DOI：
10.1093/nar/gkv1123
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发表时间：
2016-01-04
影响因子：
14.9
通讯作者：
Ciccarelli FD
中科院分区：
文献类型：
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作者：
An O;Dall'Olio GM;Mourikis TP;Ciccarelli FD
癌症基因网络（NCG，http：//ncg.kcl.ac.uk/）是从科学文献中获得的癌症基因的人工管理库。由于癌症基因组数据的不断增加，我们引入了一种更强大的程序来从已发表的癌症突变筛查中提取癌症基因，两位策展人独立审查了每份出版物。NCG 5.0版（2015年8月）从175项已发表的研究中收集了1571个癌症基因，这些研究描述了来自49种癌症类型和24个原发部位的13315个癌症样本的188个突变筛查。除了收集癌症基因外，NCG还提供了支持这些基因在癌症中作用的实验验证信息，并注释了它们的特性（可复制性，进化起源，表达谱，功能以及与蛋白质和miRNA的相互作用）。
The Network of Cancer Genes (NCG, http://ncg.kcl.ac.uk/) is a manually curated repository of cancer genes derived from the scientific literature. Due to the increasing amount of cancer genomic data, we have introduced a more robust procedure to extract cancer genes from published cancer mutational screenings and two curators independently reviewed each publication. NCG release 5.0 (August 2015) collects 1571 cancer genes from 175 published studies that describe 188 mutational screenings of 13 315 cancer samples from 49 cancer types and 24 primary sites. In addition to collecting cancer genes, NCG also provides information on the experimental validation that supports the role of these genes in cancer and annotates their properties (duplicability, evolutionary origin, expression profile, function and interactions with proteins and miRNAs).