The Role of Iraqi Dust in Inducing Lung Injury in United States Soldiers-An Interdisciplinary Study.
The Role of Iraqi Dust in Inducing Lung Injury in United States Soldiers-An Interdisciplinary Study.
复制标题
伊拉克灰尘在诱发美国士兵肺部损伤中的作用——一项跨学科研究。
DOI：
10.1002/2017gh000071
复制
发表时间：
2017
期刊：
影响因子：
4.8
通讯作者：
Schoonen,MartinAA
中科院分区：
文献类型：
--
作者：
Harrington,AndreaD;Schmidt,MillicentP;Szema,AnthonyM;Galdanes,Karen;Tsirka,StellaE;Gordon,Terry;Schoonen,MartinAA
从大中东返回的美国士兵患有呼吸道疾病，从新发哮喘到缩窄性细支气管炎。这些疾病的病因尚不清楚。进行了一项研究，以确定当地矿物粉尘在士兵部署在伊拉克期间和之后患上异常呼吸道疾病方面的可能作用。在胜利营，伊拉克（胜利营灰尘）的燃烧坑附近获得的灰尘样品的特点是化学和矿物学。为了比较，还收集了来自加州州欧文堡的灰尘样品（欧文堡灰尘）。对粉尘样品产生活性氧（ROS）的能力以及它们在人肺上皮细胞中产生炎症应激反应（ISR）的能力进行了定量。这两个样品都由常见的硅酸盐和碳酸盐矿物组成，并含有重金属，其浓度范围预计为矿物粉尘。每个样品产生的ISR在惰性材料范围内，产生的应力最小，与碳酸盐相相关。基于这一样本的发现表明，疾病的起源不是由颗粒产生ROS的能力驱动的。然而，很可能是颗粒过载和相关并发症，或内毒素广泛有助于发病机制。
United States soldiers are returning from the Greater Middle East with respiratory illnesses ranging from new onset asthma to constrictive bronchiolitis. The etiologies of the diseases are unknown. A study was conducted to determine the possible role of local mineral dust in the development of abnormal respiratory illnesses in soldiers during and after deployment in Iraq. A dust sample obtained in proximity to a burn pit in Camp Victory, Iraq (Camp Victory dust) was characterized both chemically and mineralogically. For comparison, a dust sample from Fort Irwin, California (Fort Irwin dust) was also collected. The ability of the dust samples to generate reactive oxygen species (ROS) was quantified, as well as their ability to generate an inflammatory stress response (ISR) in human lung epithelial cells. Both samples are composed of common silicate and carbonate minerals and contain heavy metals with concentration ranges expected for mineral dust. The ISR generated by each sample was within the range of inert material with the minimal stress generated associated with the carbonate phases. The findings based on this one sample suggest that the origin of the disease is not driven by the particles ability to generate ROS. However, it is likely that particle overload and associated complications, or endotoxin contributes extensively to pathogenesis.