Maternal corticosterone influences behavior, stress response and corticosteroid receptors in the female rat
Maternal corticosterone influences behavior, stress response and corticosteroid receptors in the female rat
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DOI：
10.1016/s0091-3057(02)00755-4
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发表时间：
2002-08-01
影响因子：
3.6
通讯作者：
Angelucci, L
中科院分区：
文献类型：
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作者：
Catalani, A;Casolini, P;Angelucci, L
在婴儿期，糖皮质激素已被证明影响下丘脑-垂体-肾上腺（HPA）轴的活动和行为。HPA轴的活动和行为的许多方面都表现出重要的生理性别差异。在我们以前的研究中，高皮质酮血症母亲的雄性后代表现出长期的学习和肾上腺皮质活动的变化。根据这些发现，本研究旨在确定糖皮质激素在雌性大鼠生命早期阶段的长期影响。将皮质酮（200 μ g/ml）添加到母鼠的饮用水中。雌性后代表现出较低的肾上腺皮质分泌反应的压力，改善学习（21、30和90天的水迷宫; 15个月时的主动回避）和减少焦虑情况下的恐惧（1个月和15个月时的暗光试验; 3个月时的条件性饮酒抑制;加上15个月时的迷宫），从21日龄到15个月龄，但在此之前没有。海马肾上腺皮质激素受体无差异。这些结果，加上以前的数据，男性后代，表明母体高皮质酮血症对激素应激反应和行为的结果是相似的男性和女性，但对HPA轴活动的某些方面的影响是性别依赖性的。这些差异的可能解释进行了讨论。(C)2002年爱思唯尔科技有限公司All rights reserved.
In infancy, glucocorticoids have been shown to affect hypothalamus-pituitary-adrenal (HPA) axis activity and behavior. Both the activity of the HPA axis and many aspects of behavior exhibit important gender-dependent differences physiologically. In our previous studies, male offspring of hypercorticosteronemic mothers show long-lasting changes of learning as well as adrenocortical activity. In the light of these findings, this study aims to determine the long-term effects of glucocorticoids in the early stages of life in female rats. Corticosterone (200 mug/ml) was added to the drinking water of the dams. Female offspring exhibited lower adrenocortical secretory response to stress, improvement in learning (water maze at 21, 30 and 90 days; active avoidance at 15 months) and reduced fearfulness in anxiogenic situations (dark-light test at 1 and 15 months; conditioned suppression of drinking at 3 months; plus maze at 15 months) after weaning, from 21 days up to 15 months of age, but not before. No difference in hippocampal adrenocorticoid receptors was observed. These results, together with previous data on male offspring, show that the outcomes of maternal hypercorticosteronemia on hormonal stress response and behavior are similar in males and females, but the effects on some aspects of the HPA axis activity are gender-dependent. Possible explanations for these differences are discussed. (C) 2002 Elsevier Science Inc. All rights reserved.