Relative potency of dopamine agonists on autoreceptor function in various brain regions of the rat.
Relative potency of dopamine agonists on autoreceptor function in various brain regions of the rat.
复制标题
多巴胺激动剂对大鼠不同脑区自身受体功能的相对效力。
DOI：
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发表时间：
1983
影响因子：
3.5
通讯作者：
C. Paul
中科院分区：
文献类型：
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作者：
T. Westfall;L. Naes;C. Paul
在纹状体、伏隔核、嗅结节和内侧基底下丘脑等含有多巴胺末端的脑区制备的切片和突触体中，研究了阿波啡、肾上腺素、多巴胺、匹利贝地尔、来曲曲、溴隐亭等6种多巴胺激动剂对[3H]酪氨酸与多巴胺结合的影响。我们观察到，所有这些药物都能导致大脑不同区域多巴胺合成的减少。儿茶酚胺激动剂阿波啡、肾上腺素和多巴胺对中边缘结构多巴胺合成的抑制作用强于纹状体。另一方面，阿波啡和肾上腺碱在下丘脑内侧基底部的作用较弱，而多巴胺的作用较强。麦角碱类药物在所有结构中均为弱激动剂。综上所述，与黑质纹状体多巴胺通路相比，自受体对多巴胺合成的调节在中边缘区更为活跃，而在中隆起区可能缺乏自受体。
The effect of six dopamine agonists including apomorphine, epinine, dopamine, piribedil, lergotrile and bromocriptine on the incorporation of [3H]tyrosine into dopamine was studied in slices and synaptosomes prepared from various brain areas containing dopamine terminals including striatum, nucleus accumbens, olfactory tubercle and medial basal hypothalamus. It was observed that all of these drugs were active in causing a decrease in dopamine synthesis in these various brain areas. The catecholamine agonists apomorphine, epinine and dopamine were more potent in inhibiting dopamine synthesis in the mesolimbic structures than in the striatum. On the other hand, apomorphine and epinine were less potent while dopamine was more potent in the medial basal hypothalamus. The ergoline drugs were weak agonists in all structures studied. It is concluded that autoreceptor regulation of dopamine synthesis is more active in the mesolimbic compared with the nigrostriatal dopamine pathway while autoreceptors may be absent in the median eminence.