Human mesenchymal stem cells as a stabte source of VEGF-producing cells
Human mesenchymal stem cells as a stabte source of VEGF-producing cells
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DOI：
10.1002/term.79
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发表时间：
2008-06-01
影响因子：
3.3
通讯作者：
Ohgushi, Hajime
中科院分区：
文献类型：
--
作者：
Kagiwada, Harumi;Yashiki, Tetsuya;Ohgushi, Hajime
血管内皮生长因子（VEGF）是一种正性调节因子，在血管生成中起着至关重要的作用。我们证明，VEGF在人骨髓间充质干细胞（hMSCs）培养物中高度表达，并且在长时间培养期间（检查至第10代）保持高表达水平。我们还证实，在体内移植到免疫缺陷小鼠的hMSCs可以生存和分泌人VEGF。这些发现表明，hMSCs的植入是一种实用的手段，作为VEGF的生产来源，并可能是有效的新生血管。版权所有（C）2008约翰威利父子有限公司
Vascular endothelial growth factor (VEGF) is a positive regulator and plays a crucial role in angiogenesis. We demonstrate that VEGF was highly expressed in cultures of human bone marrow-derived mesenchymal stem cells (hMSCs) and the high expression level was maintained during prolonged culture periods (checked up to passage 10). We also confirmed that in vivo hMSCs engrafted into immunodeficient mice could survive and secreted human VEGF. These findings suggest that implantation of hMSCs is a practical means as a source of VEGF production and might be effective in neoangiogenesis. Copyright (C) 2008 John Wiley & Sons, Ltd.