Racial differences in erythrocyte cation transport.
Racial differences in erythrocyte cation transport.
复制标题
红细胞阳离子转运的种族差异。
作者：
A. Weder;B. Torretti;Stevo Julius
在120名白色和黑色血压正常和高血压患者中测定红细胞含量和哇巴因不敏感的转运途径。白色高血压患者的平均最大钠刺激锂-钠反向转运率高于白色血压正常者，且反向转运与白人的平均动脉压显著正相关。在黑人血压正常者和高血压者中发现了与白色血压正常者相似的值，并且反向转运与黑人的血压没有显著相关性。与黑人相比，白人的被动锂外排速率常数更大，并且该差异与血压水平或性别无关。哇巴因不敏感，呋塞米敏感的钠和钾流出未被发现改变高血压。在黑人中，呋塞米敏感的钠外排率较低，但呋塞米敏感的钾外排没有类似的抑制。虽然白色受试者表现出钠和钾外流之间的密切相关性，但黑人则不然。进一步研究细胞钠和钾代谢的这些差异，可能会提供线索的发病机制的种族差异，在全身钠处理。
Erythrocyte contents and ouabain-insensitive transport pathways were measured in 120 white and black normotensives and hypertensives. Mean maximal sodium-stimulated lithium-sodium countertransport rate was higher in white hypertensives than in white normotensives, and countertransport was significantly positively correlated with mean arterial pressure in whites. Values similar to those in white normotensives were found in both black normotensives and hypertensives, and countertransport was not significantly correlated with blood pressure in blacks. The rate constant for passive lithium efflux was greater in whites as compared to blacks, and the difference was not related to blood pressure level or sex. Ouabain-insensitive, furosemide-sensitive sodium and potassium effluxes were not found to be altered in hypertension. Furosemide-sensitive sodium efflux rate was lower in blacks but furosemide-sensitive potassium efflux was not similarly depressed. While white subjects demonstrated a close correlation between sodium and potassium effluxes, blacks did not. Further study of these differences in the cellular metabolism of sodium and potassium may provide clues to the pathogenesis of racial dissimilarities in total body sodium handling.
高血压大学生钠锂逆转运增加。
DOI：
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发表时间：
1983
期刊：
JAMA : the journal of the American Medical Association
影响因子：
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作者：
Cooper,R;LeGrady,D;Nanas,S;Trevisan,M;Mansour,M;Histand,P;Ostrow,D;Stamler,J
通讯作者：
Stamler,J