Dopamine D2 Receptor Genotype (C957T) and Habitual Consumption of Sugars in a Free-Living Population of Men and Women
Dopamine D2 Receptor Genotype (C957T) and Habitual Consumption of Sugars in a Free-Living Population of Men and Women
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DOI：
10.1159/000276991
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发表时间：
2009-01-01
影响因子：
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通讯作者：
El-Sohemy, Ahmed
中科院分区：
文献类型：
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作者：
Eny, Karen M.;Corey, Paul N.;El-Sohemy, Ahmed
背景/目的：多巴胺 D2 受体 (DRD2) 与调节高糖食物的奖赏效应有关。本研究的目的是确定 DRD2 基因的变异是否会影响自由生活人群的糖类消费习惯。方法：20-29 岁的白人男性 (n = 96) 和女性 (n = 217) 完成了为期 1 个月的食物频率调查问卷，并对 DRD2 基因中的 C957T 多态性进行了基因分型。使用事后 Tukey 检验的协方差分析来比较调整潜在混杂因素的基因型之间的营养摄入量。结果：在男性中，CC、CT 和 TT 基因型男性的蔗糖消耗量分别为 60 +/- 6、48 +/- 4 和 39 +/- 5 g/天，纯合子之间存在显着差异 (p = 0.03)，表明存在加性遗传模式。在女性中，CC、CT 和 TT 基因型的蔗糖消耗量分别为 42 +/- 4、53 +/- 2 和 44 +/- 4 g/天，其中 CC 和 CT 差异显着 (p = 0.02)，表明存在部分杂种优势遗传模式。蛋白质或脂肪没有观察到差异。结论：这些发现表明 DRD2 的遗传变异影响食物选择，并可能解释糖消耗的一些个体间差异。版权所有 (C) 2010 S Karger AG，巴塞尔
Background/Aims: The dopamine D2 receptor (DRD2) has been implicated in modulating the rewarding effects of foods high in sugar. The purpose of this study was to determine whether a variation in the DRD2 gene affects habitual consumption of sugars in a free-living population. Methods: Caucasian men (n = 96) and women (n = 217) 20-29 years of age completed a 1-month food frequency questionnaire and were genotyped for the C957T polymorphism in the DRD2 gene. Analyses of covariance with post-hoc Tukey tests were used to compare nutrient intakes between genotypes adjusting for potential confounders. Results: Among men, consumption of sucrose was 60 +/- 6, 48 +/- 4, and 39 +/- 5 g/day for those with the CC, CT and TT genotypes, respectively, with a significant difference between the homozygotes (p = 0.03), suggesting an additive mode of inheritance. Among women, sucrose consumption was 42 +/- 4, 53 +/- 2, and 44 +/- 4 g/day for the CC, CT and TT genotypes, respectively, with CC and CT differing significantly (p = 0.02), suggesting a partial heterosis mode of inheritance. No differences were observed for protein or fat. Conclusions: These findings suggest that genetic variation in DRD2 influences food selection and may explain some of the interindividual differences in sugar consumption. Copyright (C) 2010 S Karger AG, Basel