CLINICAL AND IMMUNOLOGICAL EFFECTS OF MONTHLY ADMINISTRATION OF INTRAVENOUS CYCLOPHOSPHAMIDE IN SEVERE SYSTEMIC LUPUS-ERYTHEMATOSUS
CLINICAL AND IMMUNOLOGICAL EFFECTS OF MONTHLY ADMINISTRATION OF INTRAVENOUS CYCLOPHOSPHAMIDE IN SEVERE SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1056/nejm198806023182203
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发表时间：
1988-06-02
影响因子：
158.5
通讯作者：
FOX, DA
中科院分区：
文献类型：
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作者：
MCCUNE, WJ;GOLBUS, J;FOX, DA
尽管使用高剂量皮质类固醇治疗，影响肾脏或中枢神经系统的严重系统性红斑狼疮仍可能导致器官衰竭或死亡。为了评估静脉注射环磷酰胺在这种情况下的临床和免疫学效果，我们对 9 名患者进行了为期六个月的每月静脉输注环磷酰胺的治疗。入组时和随访时的特征比较显示肌酐清除率有所改善（通过配对 t 检验）（每分钟 66 毫升与 96 毫升，P
Severe systemic lupus erythematosus affecting the kidney or central nervous system may lead to organ failure or death despite treatment with high doses of corticosteroids. To evaluate the clinical and immunologic effects of intravenous cyclophosphamide in this setting, we treated nine patients with monthly intravenous infusions of cyclophosphamide for six months. A comparison of characteristics at entry and follow-up revealed improvements (by paired t-test) in creatinine clearance (66 vs. 96 ml per minute, P