Self-enhancement processing in the default network: a single-pulse TMS study.
Self-enhancement processing in the default network: a single-pulse TMS study.
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DOI：
10.1007/s00221-012-3249-7
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发表时间：
2012-11
影响因子：
2
通讯作者：
Lisanby, Sarah H.
中科院分区：
文献类型：
--
作者：
Luber, Bruce;Lou, Hans C.;Keenan, Julian P.;Lisanby, Sarah H.
积极的自我评价及其与心理健康的关系已经做了很多研究。然而，人们对其神经基础知之甚少。成像研究表明，大脑的默认网络与自我相关的处理有关，而默认网络的一部分，内侧前额叶皮层（MPFC），特别与自我评价有关。在这里，我们使用经颅磁刺激（TMS）因果证明，这个网络，特别是MPFC，涉及自我评价处理。在第一个实验中，27名健康志愿者判断形容词是否描述了他们自己或他们最好的朋友，并发现了一个强大的自我增强偏见效应。在第二个实验中，单脉冲TMS应用于三个位置（MPFC和左，右顶叶皮层）在不同的健康志愿者组，而他们执行的形容词任务。在每个试验中，TMS被应用在相对于形容词的起始的五个不同时间之一，范围从0- 480毫秒。经颅磁刺激以一种特定于地点和潜伏期的方式影响自我增强偏见：在MPFC，自我增强偏见实际上在160毫秒时逆转，受试者更喜欢他们最好的朋友。因此，经颅磁刺激可能用于调查自我评价异常的精神疾病领域，可能作为一种诊断工具。此外，本研究结合我们以前的研究结果，因果地证明了两种类型的自我相关的加工在默认网络，一个中心在顶叶皮层，涉及检索的自我相关的协会，和其他MPFC为中心，涉及自我评价的处理。
Much research has been done on positive self-evaluation and its relationship to mental health. However, little is known about its neural underpinnings. Imaging studies have suggested that the brain’s default network is involved with self-related processing, and that one portion of the default network, medial prefrontal cortex (MPFC), is particularly involved with self-evaluation. Here we used transcranial magnetic stimulation (TMS) to causally demonstrate that this network, and particularly MPFC, is involved with self-evaluative processing. In a first experiment, 27 healthy volunteers judged whether adjectives, evenly-divided between desirable and undesirable traits, described themselves or their best friends, and a robust self-enhancement bias effect was found. In a second experiment, single-pulse TMS was applied targeting three locations (MPFC and left and right parietal cortex) in a different group of healthy volunteers while they performed the adjective task. In each trial, TMS was applied at one of five different times relative to onset of the adjective ranging from 0–480ms. TMS affected self-enhancement bias in a site- and latency-specific manner: at MPFC, the self-enhancement bias actually reversed at 160ms, with subjects favoring their best friend over themselves. TMS may thus be of use in investigating areas of mental illness in which self-evaluation is abnormal, potentially as a diagnostic tool. In addition, the present study, combined with our previous reports causally demonstrate two kinds of self-related processing within the default network, one centered in parietal cortex and concerned with retrieval of self-related associations, and the other MPFC-centered, involved in self-evaluative processing.
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影响因子：
2
作者：
Beer, J;Blakemore, C;Liotti, M
通讯作者：
Liotti, M
影响因子：
3.2
作者：
D'Argembeau, Arnaud;Ruby, Perrine;Salmon, Eric
通讯作者：
Salmon, Eric
DOI：
10.1073/pnas.071043098
发表时间：
2001-03-27
影响因子：
11.1
作者：
Gusnard, DA;Akbudak, E;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
8.2
作者：
Craik, FIM;Moroz, TM;Kapur, S
通讯作者：
Kapur, S
影响因子：
7.6
作者：
ANDERSON, NH
通讯作者：
ANDERSON, NH