Biofunctionalized two-dimensional Ti3C2 MXenes for ultrasensitive detection of cancer biomarker
Biofunctionalized two-dimensional Ti3C2 MXenes for ultrasensitive detection of cancer biomarker
复制标题
用于超灵敏检测癌症生物标志物的生物功能化二维 Ti3C2 MXene
DOI：
10.1016/j.bios.2018.08.076
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发表时间：
2018-12-15
影响因子：
12.6
通讯作者：
Salama, Khaled N.
中科院分区：
文献类型：
--
作者：
Kumar, Saurabh;Lei, Yongjiu;Salama, Khaled N.
In this work, ultrathin Ti3C2-MXene nanosheets were synthesized by minimally intensive layer delamination methods, and uniformly functionalized with aminosilane (f-Ti3C2-MXene) to provide a covalent binding for the immobilized bio-receptor (anti-CEA) for label free, ultrasensitive detection of cancer biomarker (carcinoem-bryonic antigen, CEA). The effect of different redox probes on the electrochemical behavior of f-Ti3C2-MXene was investigated and found that hexaammineruthenium ([Ru(NH3)(6)](3+)) is the preferable redox probe for bio-sensing. The fabricated biofunctionalized Ti3C2-MXene exhibits a linear detection range of 0.0001-2000 ng mL(-1) with sensitivity of 37.9 mu A ng(-1) mL cm(-2) per decade. The wider linear detection range of our f-Ti3C2-MXene is not only higher than previously reported pristine 2D nanomaterials, but is even comparable to other hybrid 2D nanomaterials. We believe that this work opens a new window for development of MXene-based highly sensitive DNA, aptamer, enzyme, antibody, and cell based biosensors, and could be further used in drug delivery application.
