ROUTE OF DELIVERY OF PHENYLALANINE INFLUENCES ITS EFFECT ON SHORT-TERM FOOD-INTAKE IN ADULT MALE-RATS
ROUTE OF DELIVERY OF PHENYLALANINE INFLUENCES ITS EFFECT ON SHORT-TERM FOOD-INTAKE IN ADULT MALE-RATS
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DOI：
10.1093/jn/119.10.1519
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发表时间：
1989-10-01
影响因子：
4.2
通讯作者：
ANDERSON, GH
中科院分区：
文献类型：
--
作者：
BIALIK, RJ;LI, ETS;ANDERSON, GH
测定了苯丙氨酸（Phe）对雄性大鼠血浆和脑中Phe和酪氨酸（Tyr）水平以及短期摄食量的影响，皮下（s.c.）和腹膜内（i. p.）局与作为对照的等摩尔丙氨酸（Ala）相比，当腹膜内给予Phe时，Phe以90 mg/kg体重的剂量显著抑制进食，但当i.g.给药时，高达720 mg/kg体重的剂量没有影响。或s.c.通过i.g.或s.c.与腹膜内注射（90 mg/kg体重）后相比，经皮给药后血浆和脑中的Phe水平更高。此外，i.g. Phe（720 mg/kg体重）等于或高于i. p. Phe（90 mg/kg体重）后的水平。我们的结论是，管理的途径是一个重要的变量影响的影响苯丙氨酸的摄食行为，这些影响是不容易解释的血浆或大脑苯丙氨酸和酪氨酸浓度。
The effect of phenylalanine (Phe) on plasma and brain Phe and tyrosine (Tyr) levels and on short-term food intake in male rats was measured after intragastric (i.g.), subcutaneous (s.c.) and intraperitoneal (i.p.) administration. Compared to equimolar alanine (Ala), which served as the control, Phe significantly suppressed feeding at a dose of 90 mg/kg body wt when given i.p., but doses up to 720 mg/kg body wt had no effect when given i.g. or s.c. The high doses of Phe given by the i.g. or s.c. route resulted in higher levels of Phe in both plasma and brain than those following i.p. injection (90 mg/kg body wt). Furthermore, brain Tyr levels after i.g. Phe (720 mg/kg body wt) were equal to or higher than after i.p. Phe (90 mg/kg body wt). We conclude that the route of administration is an important variable influencing the effects of Phe on feeding behavior, and that these effects are not readily explained by plasma or brain Phe and Tyr concentrations.