REGULATION OF PLASMA-CHOLESTEROL BY LIPOPROTEIN RECEPTORS
REGULATION OF PLASMA-CHOLESTEROL BY LIPOPROTEIN RECEPTORS
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DOI：
10.1126/science.6261329
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
GOLDSTEIN, JL
中科院分区：
文献类型：
--
作者：
BROWN, MS;KOVANEN, PT;GOLDSTEIN, JL
脂蛋白运输系统是理解基因、饮食和激素相互作用调节人类血浆胆固醇水平的机制的关键。该系统的关键组成部分是肝脏和肝外组织中的脂蛋白受体，它们介导携带胆固醇的脂蛋白的摄取和降解。降低胆固醇的药物可以增加脂蛋白受体的数量，从而提高血浆胆固醇的处理效率。脂蛋白受体的调节可用于人类高胆固醇血症和动脉粥样硬化的药理学治疗。
The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man. Crucial components of this system are lipoprotein receptors in the liver and extrahepatic tissues that mediate the uptake and degradation of cholesterol-carrying lipoproteins. The number of lipoprotein receptors, and hence the efficiency of disposal of plasma cholesterol, can be increased by cholesterol-lowering drugs. Regulation of lipoprotein receptors can be exploited pharmacologically in the therapy of hypercholesterolemia and atherosclerosis in man.