SALT EFFECTS ON NUCLEIC-ACIDS
SALT EFFECTS ON NUCLEIC-ACIDS
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DOI：
10.1016/0959-440x(95)80093-x
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发表时间：
1995-06-01
影响因子：
6.8
通讯作者：
HONIG, B
中科院分区：
文献类型：
--
作者：
SHARP, KA;HONIG, B
盐依赖性静电效应是决定核酸的稳定性、结构、反应性和结合行为的主要因素。越来越详细的理论方法，特别是那些基于Monte Carlo和Poisson-Boltzmann方法，结合强大的计算算法，被用来研究分子的形状，电荷分布和介电性质如何影响周围水溶液中的离子分布，以及它们如何在配体结合，结构转变和其他生物学上重要的反应中发挥作用。这些研究表明，包含有关核酸及其配体的详细结构信息对于改进核酸静电模型至关重要，并且更好地处理离子气氛和介电效应也非常重要。
Salt-dependent electrostatic effects are a major factor in determining the stability, structure, reactivity, and binding behavior of nucleic acids. Increasingly detailed theoretical methods, especially those based on Monte Carlo and Poisson-Boltzmann methodologies, combined with powerful computational algorithms are being used to examine how the shape, charge distribution and dielectric properties of the molecules affect the ion distribution in the surrounding aqueous solution, and how they play a role in ligand binding, structural transitions and other biologically important reactions. These studies indicate that inclusion of detailed structural information about the nucleic acid and its ligands is crucial for improving models of nucleic acid electrostatics, and that better treatment of the ion atmosphere and dielectric effects is also of major importance.