Plant Alkaloids as an Emerging Therapeutic Alternative for the Treatment of Depression.
Plant Alkaloids as an Emerging Therapeutic Alternative for the Treatment of Depression.
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DOI：
10.3389/fphar.2016.00028
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发表时间：
2016
影响因子：
5.6
通讯作者：
Pervaiz A
中科院分区：
文献类型：
--
作者：
Perviz S;Khan H;Pervaiz A
抑郁症是一种异质性情绪障碍，已被分类并以多种方式治疗。虽然，许多合成药物被用作临床抑郁症患者的标准治疗方法，但它们的副作用会影响治疗效果和患者的依从性。与合成药物不同，草药因其广泛的适用性和副作用最小的治疗效果而在全球范围内广泛使用，这反过来又启动了有关抗抑郁活性的科学研究。这篇综述主要基于过去十年的文献，旨在探索植物生物碱（丰富的次级代谢物）作为一种新兴的抑郁症治疗方法的临床前概况。
Depression is a heterogeneous mood disorder that has been classified and treated in a variety of ways. Although, a number of synthetic drugs are being used as standard treatment for clinically depressed patients, but they have adverse effects that can compromise the therapeutic treatments and patient's compliance. Unlike, synthetic medications, herbal medicines are widely used across the globe due to their wide applicability and therapeutic efficacy associated with least side effects, which in turn has initiated the scientific research regarding the antidepressant activity. This review is mostly based on the literature of the last decade, aimed at exploring the preclinical profile of plant-based alkaloids (the abundant secondary metabolite) as an emerging therapy for depression.