Distinct and Overlapping Functional Zones in the Cerebellum Defined by Resting State Functional Connectivity
Distinct and Overlapping Functional Zones in the Cerebellum Defined by Resting State Functional Connectivity
复制标题
DOI：
10.1093/cercor/bhp157
复制
发表时间：
2010-04-01
期刊：
影响因子：
3.7
通讯作者：
Johansen-Berg, Heidi
中科院分区：
文献类型：
--
作者：
O'Reilly, Jill X.;Beckmann, Christian F.;Johansen-Berg, Heidi
小脑处理来自大脑皮层不同功能区域的信息。小脑输入和输出核与前额叶、顶叶、感觉皮层以及运动和前运动皮层有联系。然而，小脑和大脑皮层之间的连接的地形在很大程度上仍未绘制，因为它相对不适合解剖学方法。我们使用静息状态功能磁共振成像来定义小脑皮层内的亚区，基于它们与大脑皮层的功能连接。我们绘制了小脑皮层的静息状态功能连通性体素图，包括前额叶、运动、体感、后顶叶、视觉和听觉皮层。我们发现小脑至少可以分为2个区域：1)初级感觉运动区（小叶V、VI和VIII），其中包含重叠的功能连接图，用于特定区域的运动、体感、视觉和听觉皮层；2)模态上区（小叶II，脚I和II），包含前额叶和后顶叶皮层重叠的功能连接图。模上区皮层的连通性是由不直接参与感觉或运动加工的额叶和顶叶皮层驱动的，包括背外侧前额叶皮层和额极，以及顶叶下小叶。
The cerebellum processes information from functionally diverse regions of the cerebral cortex. Cerebellar input and output nuclei have connections with prefrontal, parietal, and sensory cortex as well as motor and premotor cortex. However, the topography of the connections between the cerebellar and cerebral cortices remains largely unmapped, as it is relatively unamenable to anatomical methods. We used resting-state functional magnetic resonance imaging to define subregions within the cerebellar cortex based on their functional connectivity with the cerebral cortex. We mapped resting-state functional connectivity voxel-wise across the cerebellar cortex, for cerebral-cortical masks covering prefrontal, motor, somatosensory, posterior parietal, visual, and auditory cortices. We found that the cerebellum can be divided into at least 2 zones: 1) a primary sensorimotor zone (Lobules V, VI, and VIII), which contains overlapping functional connectivity maps for domain-specific motor, somatosensory, visual, and auditory cortices; and 2) a supramodal zone (Lobules VIIa, Crus I, and II), which contains overlapping functional connectivity maps for prefrontal and posterior-parietal cortex. The cortical connectivity of the supramodal zone was driven by regions of frontal and parietal cortex which are not directly involved in sensory or motor processing, including dorsolateral prefrontal cortex and the frontal pole, and the inferior parietal lobule.