Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized
Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized
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急性 B 淋巴细胞白血病细胞中 CD34 和 CD38 表达的异质性是可逆的，并且没有分层组织
DOI：
10.1186/s13045-016-0310-1
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发表时间：
2016-09-22
影响因子：
28.5
通讯作者：
Li, Peng
中科院分区：
文献类型：
--
作者：
Jiang, Zhiwu;Deng, Manman;Li, Peng
成人急性B淋巴细胞白血病（B-ALL）中白血病起始细胞的存在和鉴定仍存在争议。我们研究了成人B-ALL是否分层组织成白血病和非白血病细胞的表型不同的亚群，或是否大多数B-ALL细胞保留白血病的能力，无论他们的免疫表型配置文件。我们的研究结果表明，成人B-ALL遵循随机干细胞模型，并且B-ALL中CD 34和CD 38的表达是可逆的，并且不是分层组织的。
The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized.