Current concepts of bone formation.
Current concepts of bone formation.
复制标题
骨形成的当前概念。
DOI：
10.2106/00004623-196244060-00020
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发表时间：
1962
期刊：
影响因子：
--
通讯作者：
C. Bassett
中科院分区：
文献类型：
--
作者：
C. Bassett
本报告强调了环境对成骨过程中细胞功能的影响。然而，应该记住，环境在很大程度上控制着所有细胞的功能活动。例如，细胞膜及其所处的环境控制着进入细胞的原料。然后，这些物质在一定程度上决定了细胞可以合成和释放的产物。一旦释放，产物就会影响细胞外微环境。在结缔组织的特殊情况下，甚至产品组合的模式也可能受到该环境的影响。换句话说，细胞释放的产物依赖于遗传信息+环境。组织结构取决于细胞和环境释放的产物。环境在某种程度上取决于组织结构和细胞释放的产物。最后，可以在细胞内的遗传编码系统和数据处理中心之间进行类比。两者都有比它们在任何时候都能表达的更大的能力。两者都只能对提供给它们的材料起作用，并会对不同的刺激做出不同的反应。
The influence of environment on cell function during osteogenesis has been emphasized in this presentation. It should be remembered, however, that the milieu controls the functional activity of all cells to an important degree. For example, the cell membrane and the environment to which it is exposed control the raw materials entering the cell. These materials then determine, in part, the products that the cell can synthesize and release. Once released, the products influence the extracellular microenvironment. In the special case of connective tissues, even the pattern in which the products are put together may be influenced by that environment. To put it another way: Products released by cells are dependent upon genetic information + environment. Tissue structure is dependent upon products released by cells + environment. Environment, in part is dependent upon tissue structure + products released by cells. Finally, an analogy may be drawn between the genetic coding system within the cell and a data-processing center. Both have greater capabilities than they can express at any one time. Both are able to act only on materials provided to them and will respond in different manners following different stimuli.