Longitudinal distribution of pulmonary vascular pressures as a function of postnatal age in rabbits.
Longitudinal distribution of pulmonary vascular pressures as a function of postnatal age in rabbits.
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兔肺血管压力的纵向分布与出生后年龄的关系。
DOI：
10.1152/jappl.1991.71.6.2160
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Kaplowitz,MR
中科院分区：
文献类型：
--
作者：
Fike,CD;Kaplowitz,MR
本研究的主要目的是确定家兔肺血管压力的纵向分布是否随出生年龄的变化而变化。使用直接微穿刺技术，我们测量了不同出生年龄兔离体肺20- 80微米直径的小动脉和小静脉的压力。为了确定血管舒缩性张力的贡献，我们在每个年龄组的一些肺的灌注液中加入血管扩张剂罂粟碱。我们比较了在选择近似体内心输出量的血流速率下测量的血管压力。在未经治疗的肺中，20- 80微米直径微血管的阻力从12- 72小时（0.022 +/- 0.009 cmh20 .min.kg）下降。5 ~ 15日龄家兔（0.008±0.007 cmh20 .min.kg）。在成人中保持这个较低水平（0.013 +/- 0.008 cmh20 .min.kg.ml-1）。相比之下，在罂粟碱处理的肺中，20- 80微米直径微血管的耐药性在12- 72小时（0.007 +/- 0.005 cmh20 .min.kg）之间没有变化。ml-1)和5 ~ 15日龄家兔（0.005±0.002 cmh20 .min.kg）。ml-1)，但在5 ~ 15日龄和成年兔之间增加（0.014 +/- 0.007 cmh20 .min.kg.ml-1）。因此，血管舒缩性张力有助于家兔出生后肺血管压力分布的变化。
The major purpose of this study was to determine whether the longitudinal distribution of pulmonary vascular pressures changes with postnatal age in rabbits. Using the direct micropuncture technique, we measured pressures in 20- to 80-microns-diam arterioles and venules in isolated lungs of rabbits of different postnatal ages. To determine the contribution of vasomotor tone, we added the vasodilator papaverine to the perfusate of some lungs of each age group. We compared vascular pressures measured at blood flow rates chosen to approximate in vivo cardiac outputs. In untreated lungs, the resistance across 20- to 80-microns-diam microvessels decreased from 12- to 72-h-old (0.022 +/- 0.009 cmH2O.min.kg.ml-1) to 5- to 15-day-old rabbits (0.008 +/- 0.007 cmH2O.min.kg.ml-1) and remained at this lower level in adults (0.013 +/- 0.008 cmH2O.min.kg.ml-1). In contrast, in papaverine-treated lungs, the resistance across 20- to 80-microns-diam microvessels did not change between 12- to 72-h-old (0.007 +/- 0.005 cmH2O.min.kg.ml-1) and 5- to 15-day-old rabbits (0.005 +/- 0.002 cmH2O.min.kg.ml-1) but increased between 5- to 15-day-old and adult rabbits (0.014 +/- 0.007 cmH2O.min.kg.ml-1). Thus vasomotor tone contributed to the postnatal change in the distribution of vascular pressures across lungs of rabbits.