Carbohydrate to carbohydrate interaction in development process and cancer progression
Carbohydrate to carbohydrate interaction in development process and cancer progression
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DOI：
10.1007/s10719-012-9380-7
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发表时间：
2012-12-01
影响因子：
3
通讯作者：
Hakomori, Sen-itiroh
中科院分区：
文献类型：
--
作者：
Handa, Kazuko;Hakomori, Sen-itiroh
已知有两种类型的碳水化合物与碳水化合物相互作用（CCI）参与生物过程。一种是在不同细胞的界面细胞膜上表达的分子之间的CCI，以介导细胞与细胞的粘附，并随后诱导细胞信号传导，并且被称为反式CCI。研究表明，小鼠胚胎桑葚阶段的Le(x)与Le(x)相互作用在胚胎发育的压缩过程中发挥着重要作用。 GM3 与 Gg3 或 GM3 与 LacCer 相互作用被认为参与肿瘤细胞与内皮细胞的粘附，这被认为是肿瘤转移的关键步骤。另一种是细胞表面膜同一微域内表达的分子之间的CCI，称为顺式CCI。神经节苷脂 GM3 与表皮生长因子受体 (EGFR) N 连接聚糖的多 (> 3) GlcNAc 末端之间的相互作用已被表明是 GM3 对 EGFR 激活的抑制作用的分子机制。此外，GM3 和 GM2 的复合物已被证明可以通过与四跨膜蛋白 CD82 结合来抑制肝细胞生长因子 (HGF) 受体 cMet 的激活，从而抑制细胞运动。由于 CCI 研究仍然有限，未来将揭示更多 CCI 在发育中的生物过程和癌症进展中的例子。
Two types of carbohydrate to carbohydrate interaction (CCI) have been known to be involved in biological processes. One is the CCI between molecules expressed on interfacing cell membranes of different cells to mediate cell to cell adhesion, and subsequently induce cell signaling, and is termed trans-CCI. It has been indicated that the Le(x) to Le(x) interaction at the morula stage in mouse embryos plays an important role in the compaction process in embryonic development. GM3 to Gg3 or GM3 to LacCer interaction has been suggested to be involved in adhesion of tumor cells to endothelial cells, which is considered a crucial step in tumor metastasis. The other is the CCI between molecules expressed within the same microdomain of the cell surface membrane, and is termed cis-CCI. The interaction between ganglioside GM3, and multi (> 3) GlcNAc termini of N-linked glycans of epidermal growth factor receptor (EGFR), has been indicated as the molecular mechanism for the inhibitory effect of GM3 on EGFR activation. Also, the complex with GM3 and GM2 has been shown to inhibit the activation of hepatocyte growth factor (HGF) receptor, cMet, through its association with tetraspanin CD82, and results in the inhibition of cell motility. Since CCI research is still limited, more examples of CCI in biological processes in development, and cancer progression will be revealed in the future.