CAPILLARY PLEXUS ANOMALIES IN DIABETIC RETINOPATHY ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
CAPILLARY PLEXUS ANOMALIES IN DIABETIC RETINOPATHY ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
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DOI：
10.1097/iae.0000000000000859
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发表时间：
2015-11-01
影响因子：
3.3
通讯作者：
Tadayoni, Ramin
中科院分区：
文献类型：
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作者：
Couturier, Aude;Mane, Valerie;Tadayoni, Ramin
目的：应用光学相干断层扫描血管造影（OCTA）和荧光素血管造影（FA）对糖尿病视网膜病变（DR）患者的视网膜中央凹微血管进行分析。方法：回顾性分析14例（20只眼）DR患者的视网膜中央凹微血管的临床特征，如微动脉瘤、毛细血管无灌注区和视网膜内微血管异常。其中一些非灌注区在FA上未检测到，在OCTA上更好地界定。相反，在深丛，毛细血管无灌注区仅见于35%（7/20）的眼睛，而DR导致正常的毛细血管漩涡模式的改变在所有的眼睛。只有62%的FA上显示的微动脉瘤被OCTA检测到（P = 0.02）。FA和OCTA.Conclusion：光学相干断层扫描血管造影术可以检测DR异常的浅表和深毛细血管丛在所有的眼睛。OCTA检测微动脉瘤的能力低于FA，尽管其评估毛细血管无灌注的准确性更好，并且可以对DR进展进行适当分级。
Purpose:To analyze the foveal microvasculature in eyes with diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA) and fluorescein angiography (FA).Methods:In this retrospective study of 20 eyes of 14 patients with DR imaged using OCTA and FA, clinical features of DR such as microaneurysms, capillary nonperfusion areas, and intraretinal microvascular abnormalities were analyzed.Results:In the superficial plexus, a rarefaction of capillaries with capillary nonperfusion areas was present in all eyes. Some of these nonperfused areas were not detected on FA and were better delimited on OCTA. Conversely, in the deep plexus, capillary nonperfusion areas were seen only in 35% (7/20) of eyes, whereas DR led to an alteration of the normal capillary vortex pattern in all eyes. Only 62% of microaneurysms visualized on FA were detected by OCTA (P = 0.02). Intraretinal microvascular abnormalities were well detected by both FA and OCTA.Conclusion:Optical coherence tomography angiography allowed detecting DR anomalies in both superficial and deep capillary plexus in all eyes. The ability of OCTA to detect microaneurysms was lower than that of FA although its accuracy for assessing capillary nonperfusion was better and may enable a proper grading of DR progression.