Impact of carbon ion radiotherapy for unresectable osteosarcoma of the trunk
Impact of carbon ion radiotherapy for unresectable osteosarcoma of the trunk
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DOI：
10.1002/cncr.27451
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发表时间：
2012-09-15
期刊：
影响因子：
6.2
通讯作者：
Tatezaki, Shin-ichiro
中科院分区：
文献类型：
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作者：
Matsunobu, Akira;Imai, Reiko;Tatezaki, Shin-ichiro
背景：作者总结了不能切除的躯干骨肉瘤患者接受碳离子放疗（CIRT）的结果。方法：作者回顾性分析了1996年至2009年间78例医学上不能手术的躯干骨肉瘤患者并接受了CIRT治疗。肿瘤部位为骨盆61例，脊柱及棘旁区15例，其他部位2例。在4周内，共16个固定分数的中位应用CIRT剂量为70.4 Gray equivalent （GyE）。结果：幸存者的最小随访时间为14个月。48名患者仍然存活。5年总生存率33%，局部控制率62%。38名患者在5年内达到了临床目标量，其中8人能够在有或没有手杖的帮助下行走，6人没有止痛药。结论：CIRT似乎是治疗不可切除的躯干骨肉瘤的一种安全有效的方式，提供了良好的局部控制，提供了生存优势和良好的长期功能结果，没有不可接受的发病率。2012年癌症。(c) 2012年美国癌症协会。
BACKGROUND: The authors summarized the outcomes of patients with unresectable osteosarcoma of the trunk who received carbon ion radiotherapy (CIRT). METHODS: The authors performed a retrospective analysis of 78 patients who had medically inoperable osteosarcoma of the trunk and received treatment with CIRT between 1996 and 2009. Tumor sites included the pelvis in 61 patients, the spine and paraspinal region in 15 patients, and other sites in 2 patients. The median applied CIRT dose was 70.4 Gray equivalent (GyE) in a total of 16 fixed fractions over 4 weeks. RESULTS: The minimum duration of follow-up for survivors was 14 months. Forty-eight patients remained alive. The 5-year overall survival rate was 33%, and the local control rate was 62%. Thirty-eight patients who had a clinical target volume 5 years, 8 were able to walk with or without the help of a cane, and 6 were free from pain killers. CONCLUSIONS: CIRT appeared to be a safe and effective modality for the management of unresectable osteosarcoma of the trunk, providing good local control and offering a survival advantage and good long-term functional results without unacceptable morbidity. Cancer 2012. (c) 2012 American Cancer Society.