Hemispheric asymmetry in cognitive division of anterior cingulate cortex: A resting-state functional connectivity study
Hemispheric asymmetry in cognitive division of anterior cingulate cortex: A resting-state functional connectivity study
复制标题
前扣带皮层认知分裂的半球不对称：静息态功能连接研究
DOI：
10.1016/j.neuroimage.2009.05.080
复制
发表时间：
2009-10-01
期刊：
影响因子：
5.7
通讯作者：
Zang, Yufeng
中科院分区：
文献类型：
--
作者：
Yan, Hao;Zuo, Xi-Nian;Zang, Yufeng
前扣带皮层认知区（ACC-cd）通过分布式注意网络在认知控制中起着重要作用。一些神经影像学研究已经揭示了ACC的结构半球不对称性。然而，潜在的功能半球不对称的ACC仍然不太清楚。研究ACC的功能半球不对称性有助于更好地理解ACC的功能。本研究的目的是使用静息态功能磁共振成像（fMRI）检查大脑两半球与ACC-cd相关的功能网络的差异。对49名右利手健康志愿者进行了基于ROI的功能连接分析。左右侧ACC-cd与同侧大脑皮层的背外侧前额叶、顶下小叶、上级顶叶和背后扣带皮层以及对侧小脑半球的小脑扁桃体和下半月小叶的连接模式存在显著差异。具体来说，对于这些区域，我们发现右半球与ACC-cd的连接强度明显大于左半球，无论连接是积极的还是消极的。目前的结果突出了与ACC-cd相关的功能网络中存在明显的不对称性。未来的功能成像研究需要给予更多的关注，所观察到的偏侧ACC功能网络。(C)2009 Elsevier Inc. All rights reserved.
The cognitive division of anterior cingulate cortex (ACC-cd) plays an important role in cognitive control via a distributed attention network. The structural hemispheric asymmetries of ACC have been revealed by several neuroimaging studies. However potential functional hemispheric asymmetries of ACC remain less clear. Investigating the functional hemispheric asymmetries of ACC helps for a better understanding of ACC function. The aim of this study was to use resting-state functional magnetic resonance imaging (fMRI) to examine hemispheric differences in the functional networks associated with ACC-cd in the two hemispheres. ROI-based functional connectivity analysis was performed on a group of 49 right-handed healthy volunteers. The left and right ACC-cd showed significant differences in their patterns of connectivity with a variety of brain regions, including the dorsolateral prefrontal cortex, inferior parietal lobule, superior parietal lobule and dorsal posterior cingulate cortex in their ipsilateral cerebral cortex, as well as cerebellar tonsil and inferior semilunar lobule in their contralateral cerebellar hemisphere. Specifically, for these areas, we found significantly greater connectivity strength with ACC-cd in the right hemisphere than the left, regardless of whether the connection was positive or negative. The current results highlight the presence of clear asymmetries in functional networks associated with ACC-cd. Future functional imaging studies are needed to give greater attention to the lateralized ACC functional networks which are observed. (C) 2009 Elsevier Inc. All rights reserved.