Association of SNP rs17465637 on chromosome 1q41 and rs599839 on 1p13.3 with myocardial infarction in an American caucasian population.
Association of SNP rs17465637 on chromosome 1q41 and rs599839 on 1p13.3 with myocardial infarction in an American caucasian population.
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DOI：
10.1111/j.1469-1809.2011.00646.x
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发表时间：
2011-07
影响因子：
1.9
通讯作者：
Wang QK
中科院分区：
文献类型：
--
作者：
Wang AZ;Li L;Zhang B;Shen GQ;Wang QK
最近的全基因组单核苷酸多态性（SNP）关联研究（GWAS）已经确定了许多SNP与冠状动脉疾病（CAD）和心肌梗死（MI）显著相关。然而，需要在其他人群中进行许多独立的重复研究来明确证实GWAS的相关性。为了评估GWAS的相关性，我们建立了一个病例对照队列，包括1，231例特征明确的MI患者和560例未检测到冠状动脉狭窄的对照，均选自克利夫兰基因库人群。Genebank队列有足够的能力检测MI和四个GWAS SNP之间的关联，包括MIA 3基因内的rs 17465637、rs 2943634（基因间）、MTHFD 1 L中的rs6922269和SORT 1附近的rs 599839。通过TaqMan分析对SNP进行基因分型，并纳入显著协变量的后续多变量logistic回归分析显示MIA 3 SNP rs 17465637（P-adj=0.0034）和SORT 1 SNP rs 599839（P-adj=0.009）与MI显著相关。rs 599839的次要等位基因G也与LDL-C水平降低（每个等位基因5-9 mg/dL）相关，但与HDL-C或甘油三酯水平无关。SNPs rs 2943634和rs6922269与心肌梗死或血脂水平无相关性（P-adj>0.05）。我们的研究结果建立了两个SNPs，在MIA 3和SORT 1附近的rs 17465637和rs 599839作为美国Genebank高加索人群中MI的重要危险因素。
Recent genome-wide single nucleotide polymorphism (SNP) association studies (GWAS) have identified a number of SNPs that were significantly associated with coronary artery disease (CAD) and myocardial infarction (MI). However, many independent replication studies in other populations are needed to unequivocally confirm the GWAS association. To assess GWAS association, we have established a case-control cohort consisting of 1,231 well-characterized MI patients and 560 controls without detectable coronary stenosis, all selected from the Cleveland Genebank population. The Genebank cohort has a sufficient power to detect the association between MI and four GWAS SNPs, including rs17465637 within the MIA3 gene, rs2943634 (intergenic), rs6922269 in MTHFD1L, and rs599839 near SORT1. SNPs were genotyped by TaqMan assays and follow-up multivariate logistic regression analysis with incorporation of significant covariates showed significant association with MI for MIA3 SNP rs17465637 (P-adj=0.0034) and SORT1 SNP rs599839 (P-adj=0.009). The minor allele G of rs599839 was also associated with a decreased LDL-C level of 5–9 mg/dL per allele, but not with HDL-C or triglyceride levels. No association for MI or lipid levels was found for SNPs rs2943634 and rs6922269 (P-adj>0.05). Our results establish two SNPs, rs17465637 in MIA3 and rs599839 near SORT1 as significant risk factors for MI in the American Genebank Caucasian population.
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影响因子：
64.8
作者：
通讯作者：
--
冠状动脉疾病的新遗传基因座的大规模关联分析。
DOI：
10.1161/atvbaha.108.181388
发表时间：
2009-05
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Coronary Artery Disease Consortium;Samani NJ;Deloukas P;Erdmann J;Hengstenberg C;Kuulasmaa K;McGinnis R;Schunkert H;Soranzo N;Thompson J;Tiret L;Ziegler A
通讯作者：
Ziegler A
DOI：
10.1056/nejmoa072366
发表时间：
2007-08-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Samani NJ;Erdmann J;Hall AS;Hengstenberg C;Mangino M;Mayer B;Dixon RJ;Meitinger T;Braund P;Wichmann HE;Barrett JH;König IR;Stevens SE;Szymczak S;Tregouet DA;Iles MM;Pahlke F;Pollard H;Lieb W;Cambien F;Fischer M;Ouwehand W;Blankenberg S;Balmforth AJ;Baessler A;Ball SG;Strom TM;Braenne I;Gieger C;Deloukas P;Tobin MD;Ziegler A;Thompson JR;Schunkert H;WTCCC and the Cardiogenics Consortium
通讯作者：
WTCCC and the Cardiogenics Consortium
影响因子：
9.8
作者：
Wang, Q;Rao, SQ;Topol, EJ
通讯作者：
Topol, EJ
影响因子：
30.8
作者：
Willer, Cristen J.;Sanna, Serena;Abecasis, Goncalo R.
通讯作者：
Abecasis, Goncalo R.