Atipamezole, an α2-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats
Atipamezole, an α2-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats
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DOI：
10.1016/j.eplepsyres.2004.07.005
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发表时间：
2004-09-01
影响因子：
2.2
通讯作者：
Nissinen, J
中科院分区：
文献类型：
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作者：
Pitkänen, A;Narkilahti, S;Nissinen, J
α(2)-肾上腺素受体的刺激会延迟点燃（人类癫痫发生的模型）的发展。阻断 α(2)-肾上腺素受体可促惊厥，但对实验性中风后躯体运动恢复具有有益作用。我们研究了阿替美唑（一种选择性 α(2)-肾上腺素受体拮抗剂）是否会影响癫痫持续状态 (SE) 引起的脑损伤的恢复过程。这会影响癫痫发生的风险。 SE 诱导后 1 周开始载体或阿替美唑 (100 杯/公斤/小时) 治疗，并使用 Alzet 微型泵继续治疗 9 周 (n = 70)。癫痫的发展和严重程度、空间和情感学习以及组织学分析被用作结果测量。不同治疗组中患有癫痫的动物百分比没有差异。然而，在阿替美唑组中，每日癫痫发作频率较低（P
Stimulation of alpha(2)-adrenoceptors delays the development of kindling, a model of epileptogenesis in humans. Blocking alpha(2)-adrenoceptors is proconvulsant, but has beneficial effects on somatomotor recovery after experimental stroke. We investigated whether atipamezole, a selective alpha(2)-adrenoceptor antagonist, affects the recovery process from status epilepticus (SE)-induced brain damage. which affects the risk of epileptogenesis. Vehicle or atipamezole (100 mug/kg/h) treatment was started 1 week after the induction of SE and continued for 9 weeks using Alzet minipumps (n = 70). Development and severity of epilepsy, spatial and emotional learning, and histologic analysis were used as outcome measures. There were no differences in the percentage of animals with epilepsy in the different treatment groups. In the atipamezole group, however, daily seizure frequency was lower (P