IPD-IMGT/HLA Database
IPD-IMGT/HLA Database
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DOI：
10.1093/nar/gkz950
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发表时间：
2020-01-08
影响因子：
14.9
通讯作者：
Marsh, Steven G. E.
中科院分区：
文献类型：
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作者：
Robinson, James;Barker, Dominic J.;Marsh, Steven G. E.
IPD-IMGT/HLA 数据库，http://www.ebi.ac.uk/ipd/imgt/hla/，目前包含 45 个基因的 25 000 多个等位基因序列，这些基因位于人类基因组的主要组织相容性复合体 (MHC) 内。该区域是人类基因组中多态性最强的区域，其多态性水平超过了大多数其他基因。有些基因有数千个变体，现在被称为超多态性，而不仅仅是简单的多态性。 IPD-IMGT/HLA 数据库为此信息提供了一个稳定、高度可访问、用户友好的存储库，使科学界和医学界能够访问该基因系统的许多变异序列，这对于移植的成功结果至关重要。当前已知变体的数量以及正在识别的新变体数量的急剧增加，需要具有定制工具的专用资源来进行管理和发布。该数据库面临的挑战是继续提供高度策划的序列变体数据库，同时支持不断增加的提交数量和序列复杂性。为了做到这一点，传统的数据访问和呈现方法将受到挑战，并且需要利用新方法来跟上新发现的步伐。
The IPD-IMGT/HLA Database, http://www.ebi.ac.uk/ipd/imgt/hla/, currently contains over 25 000 allele sequence for 45 genes, which are located within the Major Histocompatibility Complex (MHC) of the human genome. This region is the most polymorphic region of the human genome, and the levels of polymorphism seen exceed most other genes. Some of the genes have several thousand variants and are now termed hyperpolymorphic, rather than just simply polymorphic. The IPD-IMGT/HLA Database has provided a stable, highly accessible, user-friendly repository for this information, providing the scientific and medical community access to the many variant sequences of this gene system, that are critical for the successful outcome of transplantation. The number of currently known variants, and dramatic increase in the number of new variants being identified has necessitated a dedicated resource with custom tools for curation and publication. The challenge for the database is to continue to provide a highly curated database of sequence variants, while supporting the increased number of submissions and complexity of sequences. In order to do this, traditional methods of accessing and presenting data will be challenged, and new methods will need to be utilized to keep pace with new discoveries.