Meningeal hemangiopericytomas: Long-term outcome and biological behavior
Meningeal hemangiopericytomas: Long-term outcome and biological behavior
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DOI：
10.1016/s0090-3019(02)00917-5
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发表时间：
2003-01-01
影响因子：
--
通讯作者：
Kwun, BD
中科院分区：
文献类型：
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作者：
Kim, JH;Jung, HW;Kwun, BD
背景作者对脑膜血管外皮细胞瘤进行了回顾性临床分析。长期的结果和生物学行为，包括局部复发和神经远处转移，阐明.METHOD的临床记录和影像学表现的31例脑膜血管外皮细胞瘤治疗在首尔国立大学医院和亚洲医学中心1982年和1999年之间进行了仔细审查。通过直接或电话联系和邮寄问卷确定最终结果。随访1 ~ 216个月，平均77个月。所有患者均行开颅手术，24例患者行Simpson I级或II级切除术。结果12例（38.7%）颅内复发，复发前平均104个月，复发率为99.7%（12/11）。11例为原发灶复发，1例为弥漫性软脑膜种植。5年无复发率为59.2%，切除范围是显著因素（全切除组为72.7%，不完全切除组为20.8%，p = 0.006）。在4例患者（12.9%）中，平均107个月出现神经转移。6例患者在随访期间死亡，但其中2例死于无关causes.CONCLUSIONS完全切除是减少复发的最重要因素。然而，即使在完全切除后也可能复发。由于无病期较长，因此必须进行仔细的长期随访。(C)2003年爱思唯尔科学公司
BACKGROUND The authors present a retrospective clinical analysis of meningeal hemangiopericytomas. The long-term outcome and biologic behavior, including local recurrence and extraneural distant metastasis, are elucidated.METHOD Clinical records and radiologic findings of 31 cases with meningeal hemangiopericytoma treated at Seoul National University Hospital and Asian Medical Center between 1982 and 1999 were carefully reviewed. The final outcome was determined by direct or phone contact and questionnaire by mail. The duration of follow-up was from I to 216 months (mean 77). All patients underwent craniotomy and Simpson Grade I or II resection was possible in 24 patients. Conventional radiotherapy was given in 11 patients (in 5 after total excision and in 6 for residual mass) and stereotactic radiosurgery was conducted in 6 cases.RESULTS Intracranial recurrence was seen in 12 cases (38.7%) and the mean period before the first recurrence was 104 months. The recurrence was at the primary site in 11 cases and diffuse leptomeningeal seeding occurred in the remaining case. The 5-year recurrence free rate was 59.2% and the extent of excision was the significant factor (72.7% in total excision group and 20.8% in the incomplete excision group, p = 0.006). In four patients (12.9%), extraneural metastases developed at an average of 107 months. Six patients died during the follow-up period; however, 2 of these died of unrelated causes.CONCLUSIONS Complete excision is the most important factor in reducing recurrence. However, recurrence may occur even after complete excision. Careful long-term follow-up is mandatory because of the long disease-free interval. (C) 2003 Elsevier Science Inc.