The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential.
The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential.
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DOI：
10.1016/j.ejphar.2006.09.058
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发表时间：
2007-01
影响因子：
5
通讯作者：
Kouichi Yamamoto;M. Nakai;Kyoko Nohara;A. Yamatodani
中科院分区：
文献类型：
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作者：
Kouichi Yamamoto;M. Nakai;Kyoko Nohara;A. Yamatodani
癌症化疗常常伴有严重的呕吐。抗癌药物根据其临床致吐潜力进行分类。我们已经发现高岭土的摄入行为“异食癖”类似于大鼠的呕吐。本研究的目的是研究抗癌药物的临床致吐潜力对大鼠异食癖诱导的影响。将大鼠圈养在单独的笼中，自由获取食物和高岭土颗粒，并在腹膜内给予抗癌药物（顺铂、环磷酰胺、放线菌素D、5-氟尿嘧啶和长春新碱）后3天测量每日食物和高岭土摄入量。具有高诱发呕吐潜力的药物，如顺铂和环磷酰胺，在给药当天在所有动物中诱发异食癖，并且该行为在观察期间持续。中等致吐潜力的药物，即放线菌素D和5-氟尿嘧啶，在给药后的第一天和第二天也引起异食癖，但高岭土摄入量低于高潜力的药物。在给药的第一天，具有低致吐潜力的药物曲马多斯汀略微增加了大鼠的高岭土摄入量。环磷酰胺、放线菌素D和长春新碱在观察期间引起厌食和体重下降。这些结果表明，抗癌药物引起的异食癖行为的高岭土摄入量和持续时间与药物的临床致吐潜力有关，厌食症的发生率与药物的致吐潜力无关。
Cancer chemotherapy is frequently accompanied by severe emesis. The anti-cancer drugs are classified according to their clinical emetogenic potential. We have already found that kaolin ingestion behavior “pica” is analogous to emesis in rats. The aim of this study was to examine the effects of the clinical emetogenic potential of anti-cancer drugs on the induction of the pica in rats. Rats were housed in individual cages with free access to food and kaolin pellets and the daily food and kaolin intakes were measured for 3 days after the intraperitoneal administration of anti-cancer drugs (cisplatin, cyclophosphamide, actinomycin D, 5-fluorouracil and vincristine). The drugs with high potential for inducing emesis, such as cisplatin and cyclophosphamide, induced pica in all animals on the day of administration and the behavior lasted during the observation period. The drugs with moderate emetogenic potential, i.e. actinomycin D and 5-fluorouracil, also induced pica on the first and second day after the drug administration but the kaolin intake was less than that of the drugs with high potential. Vincristine, a drug with low emetogenic potential, slightly increased the kaolin intake in rats on the only first day of the administration. Cyclophosphamide, actinomycin D and vincristine induced anorexia and decreased their body weight during the observation period. These results suggested that the both amounts of kaolin intake and duration of behavior in the anti-cancer drug-induced pica are related to the clinical emetogenic potential of the drugs and the incidence of the anorexia is not related to their emetogenic potential.