Influence of muscle wasting on oral glucose tolerance testing.
Influence of muscle wasting on oral glucose tolerance testing.
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肌肉萎缩对口服葡萄糖耐量测试的影响。
DOI：
10.1042/cs0640601
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Donohoe,K
中科院分区：
文献类型：
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作者：
Moxley,RT;Griggs,RC;Forbes,GB;Goldblatt,D;Donohoe,K
1.研究了肌肉萎缩对糖耐量的影响。口服葡萄糖耐量试验在三组废患者中进行：强直性肌营养不良（11）;肌萎缩性侧索硬化症（10）;其他下运动神经元疾病（4）。正常受试者（11）和非浪费的神经系统疾病（5）控制进行了比较研究。消瘦者的瘦体重平均下降29-36%。空腹血糖在摄入葡萄糖后120 min时略高于非空腹血糖（119.2 ± 5 vs 99.9 ± 4 mg/100 ml，P< 0.05）.除了强直性肌营养不良患者外，所有患者组均观察到正常胰岛素释放，强直性肌营养不良患者在葡萄糖给药后30至240分钟显示出明显的高胰岛素血症。这种过量的胰岛素输出不是由于强直性肌营养不良患者的瘦体重绝对下降幅度大于其他消瘦受试者。在任何消瘦组或非消瘦组中，累积胰岛素释放或胰岛素峰值与绝对或身高调整的瘦体重之间均无显著相关性。与许多研究的发现相反，在非卧床消瘦患者中仅检测到临床上不显著的葡萄糖耐受不良，并且仅强直性肌营养不良患者具有异常胰岛素释放。在这些消瘦患者中，肌肉萎缩似乎对血糖调节仅产生轻微影响，并且未观察到肌肉萎缩对胰腺胰岛素释放的典型影响。
1. The effect of muscle wasting on glucose tolerance was studied. Oral glucose tolerance testing was performed in three groups of wasted patients: myotonic dystrophy (11); amyotrophic lateral sclerosis (10); other lower motor neuron disease (four). Normal subjects (11) and non-wasted neurological disease (five) controls were studied for comparison. An average decrease of 29–36% in lean body mass was present in the wasted individuals.2. A slightly higher plasma glucose occurred at 120 min after glucose ingestion in wasted compared with non-wasted individuals (119.2 ± 5 vs 99.9 ± 4 mg/100 ml,P< 0.05).3. Normal insulin release was seen in all patient groups except those with myotonic dystrophy, who displayed marked hyperinsulinaemia from 30 to 240 min after glucose. This excessive insulin output was not due to a greater absolute decrease in lean body mass in the myotonic dystrophy patients than in the other wasted subjects. No significant correlation between the cumulative insulin release or peak insulin values and the absolute or height adjusted lean body mass was noted within any of the wasted or non-wasted groups.4. in contrast to the findings of many studies, only clinically insignificant glucose intolerance was detected in ambulatory wasted patients and only patients with myotonic dystrophy had abnormal insulin release. Muscle loss appeared to exert only a slight influence on glucose regulation in these wasted patients and no typical effect of muscular atrophy on pancreatic insulin release was noted.