Combining lymphovascular invasion with reactive stromal grade predicts prostate cancer mortality
Combining lymphovascular invasion with reactive stromal grade predicts prostate cancer mortality
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DOI：
10.1002/pros.23192
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发表时间：
2016-09-01
期刊：
影响因子：
2.8
通讯作者：
Axcrona, Ulrika
中科院分区：
文献类型：
--
作者：
Saeter, Thorstein;Vlatkovic, Ljiljana;Axcrona, Ulrika
BACKGROUNDPrevious studies suggest that lymphovascular invasion (LVI) has a weak and variable effect on prognosis. It is uncertain whether LVI, determined by diagnostic prostate biopsy, predicts prostate cancer death. Data from experimental studies have indicated that carcinoma-associated fibroblasts in the reactive stroma could promote LVI and progression to metastasis. Thus, combining LVI with reactive stromal grade may identify prostate cancer patients at high risk of an unfavorable outcome. The purpose of the present study was to examine if LVI, determined by diagnostic biopsy, alone and in combination with reactive stromal grade could predict prostate cancer death.METHODSThis population-based study included 283 patients with prostate cancer diagnosed by needle biopsy in Aust-Agder County (Norway) from 1991 to 1999. Clinical data were obtained by medical charts review. Two uropathologists evaluated LVI and reactive stromal grade. The endpoint was prostate cancer death.RESULTSPatients with LVI had marginally higher risk of prostate cancer death compared to patients without LVI (hazard ratio: 1.8, P-value=0.04). LVI had a stronger effect on prostate cancer death risk when a high reactive stromal grade was present (hazard ratio: 16.0, P-value
