Different induction of p55 and p70/75 interleukin-2 receptor subunits in human cells.
Different induction of p55 and p70/75 interleukin-2 receptor subunits in human cells.
复制标题
人体细胞中 p55 和 p70/75 白细胞介素 2 受体亚基的不同诱导。
DOI：
10.1016/0006-291x(89)91514-3
复制
发表时间：
1989
影响因子：
3.1
通讯作者：
O. Saiki
中科院分区：
文献类型：
--
作者：
T. Tanaka;S. Kishimoto;O. Saiki
There are two interleukin-2 receptor (IL-2R) subunits (p55 and p70 75) on human lymphocytes. Induction of the expressions of these IL-2R subunits was examined by the protein kinase-C (PK-C) activator (phorbol myristate acetate, PMA) and the calcium ionophore, ionomycine (IM). IM induced predominantly p70 75 expression on human T and B cells as indicated by the results of chemical crosslinking studies and binding assays. In contrast, PMA induced p55 expression significantly. These results suggest that the calcium-calmodulin and PK-C pathways regulate p70 75 and p55 expressions differently, and indicate that these intracellular signal messengers could control the responsiveness to IL-2, changing the affinity and number of receptors in vivo.
佛波二酯诱导人白细胞介素 2 受体的表达和磷酸化。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Shackelford,DA;Trowbridge,IS
通讯作者：
Trowbridge,IS