Utility of Sonazoid-Enhanced Ultrasound for the Macroscopic Classification of Hepatocellular Carcinoma: A Meta-analysis
Utility of Sonazoid-Enhanced Ultrasound for the Macroscopic Classification of Hepatocellular Carcinoma: A Meta-analysis
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Sonazoid 增强超声在肝细胞癌宏观分类中的应用：荟萃分析
DOI：
10.1016/j.ultrasmedbio.2022.06.015
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发表时间：
2022
影响因子：
2.9
通讯作者：
Xiaolin Xu
中科院分区：
文献类型：
--
作者：
Zijie Zheng;Wei Xie;Jing Tian;Jiayi Wu;Baoming Luo;Xiaolin Xu
摘要我们评估了Sonazoid增强超声（SEUS）在确定肝细胞癌（HCC）宏观分类中的诊断价值，因为它与非简单结节（非SN）型的预后不良有很强的相关性。在PubMed、EMBASE、Web of Science和科克伦图书馆数据库中检索了研究术前接受SEUS后接受HCC手术的患者的研究。5项研究共涉及334例患者，符合入选标准。总体灵敏度和特异性分别为0.74（95%置信区间[CI：0.63-0.83）和0.92（95% CI：0.82-0.97）。SEUS判断Kupffer期HCC大体分型的阳性和阴性似然比分别为9.21（95% CI：4.02-21.13）和0.28（95% CI：0.19-0.41）。SEUS确定HCC大体分类的诊断优势比为34.2（95%CI：11.64-100.51），总结受试者工作特征曲线下面积为0.87（95%CI：0.84-0.90）。亚组分析表明，小型HCC（≤30 mm）和纳入患者少于70例的研究可能比相应亚组具有更高的诊断优势比。SEUS对确定Kupffer期HCC的宏观分类具有中等诊断价值。
Abstract We assessed the diagnostic value of Sonazoid-enhanced ultrasound (SEUS) in determining the macroscopic classification of hepatocellular carcinoma (HCC) because of its strong relevance to the poor prognosis of the non-simple nodular (non-SN) type. The PubMed, EMBASE, Web of Science and Cochrane Library databases were searched for studies investigating patients who underwent surgery for HCC after undergoing SEUS pre-operatively. Five studies involving a total of 334 patients met the inclusion criteria. The summary sensitivity and specificity were 0.74 (95% confidence interval [CI: 0.63–0.83) and 0.92 (95% CI: 0.82–0.97), respectively. The positive and negative likelihood ratios of SEUS for determining the macroscopic classification of HCC in Kupffer phase were 9.21 (95% CI: 4.02–21.13) and 0.28 (95% CI: 0.19–0.41), respectively. The diagnostic odds ratio of SEUS for determining the macroscopic classification of HCC was 34.2 (95% CI: 11.64–100.51), and the area under the summary receiver operating characteristic curve was 0.87 (95% CI: 0.84–0.90). Subgroup analysis suggested that small HCCs (≤30 mm) and studies including fewer than 70 patients may be associated with a higher diagnostic odds ratio than the corresponding subsets. SEUS had moderate diagnostic value for determining the macroscopic classification of HCC in the Kupffer phase.