Total Synthesis of Mycocyclosin
Total Synthesis of Mycocyclosin
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DOI：
10.1021/ol300831t
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发表时间：
2012-05-04
期刊：
影响因子：
5.2
通讯作者：
Hutton, Craig A.
中科院分区：
文献类型：
--
作者：
Cochrane, James R.;White, Jonathan M.;Hutton, Craig A.
The first total synthesis of mycocyclosin, a diketopiperazine natural product isolated from M. tuberculosis, is described. While direct oxidative coupling of tyrosine phenolic groups was unsuccessful, construction of the highly strained bicyclic framework was successfully accomplished through an intramolecular Miyaura-Suzuki cross-coupling to generate the biaryl linkage.
