The effect of maternal smoking and drinking during pregnancy upon 3H-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome:: Initial observations in a high risk population
The effect of maternal smoking and drinking during pregnancy upon 3H-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome:: Initial observations in a high risk population
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DOI：
10.1111/j.1750-3639.2007.00093.x
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发表时间：
2008-01-01
期刊：
影响因子：
6.4
通讯作者：
Kinney, Hannah C.
中科院分区：
文献类型：
--
作者：
Duncan, Jhodie R.;Randall, Leslie L.;Kinney, Hannah C.
北部平原美洲印第安人婴儿猝死综合症（SIDS）的高发病率（3.5/1000）可能反映了怀孕期间吸烟和饮酒的高发生率。尼古丁（香烟的一种神经毒性成分）和酒精会对动物的烟碱受体结合和随后的胆碱能发育产生不利影响。我们测量了美洲印第安人 SIDS (n = 27) 和对照 (n = 6) 16 个脑干核中的 H-3-尼古丁受体结合情况。在与心肺控制相关的五个核中，H-3-烟碱结合随着饮酒次数的增加而减少（P < 0.03）。除了产前暴露的分层之外，与对照相比，SIDS 中的结合没有差异。与未接触香烟烟雾的对照组相比，接触香烟烟雾的对照组在三个对唤醒至关重要的中脑桥核中的结合减少（P < 0.04）；有或没有暴露的 SIDS 病例之间没有差异。这项研究表明，无论死因如何，母亲吸烟和饮酒都会影响婴儿脑干中的 H-3-烟碱结合。它还表明，SIDS 病例无法对母亲吸烟做出反应，而对照组则出现“正常”减少。未来的研究需要确定不良产前暴露在 SIDS 脑干神经化学改变中的作用。
The high rate of the sudden infant death syndrome (SIDS) in American Indians in the Northern Plains (3.5/1000) may reflect the high incidence of cigarette smoking and alcohol consumption during pregnancy. Nicotine, a neurotoxic component of cigarettes, and alcohol adversely affect nicotinic receptor binding and subsequent cholinergic development in animals. We measured H-3-nicotine receptor binding in 16 brainstem nuclei in American Indian SIDS (n = 27) and controls (n = 6). In five nuclei related to cardiorespiratory control, H-3-nicotinic binding decreased with increasing number of drinks (P < 0.03). There were no differences in binding in SIDS compared with controls, except upon stratification of prenatal exposures. In three mesopontine nuclei critical for arousal there were reductions (P < 0.04) in binding in controls exposed to cigarette smoke compared with controls without exposure; there was no difference between SIDS cases with or without exposure. This study suggests that maternal smoking and alcohol affects H-3-nicotinic binding in the infant brainstem irrespective of the cause of death. It also suggests that SIDS cases are unable to respond to maternal smoking with the "normal" reduction seen in controls. Future studies are needed to establish the role of adverse prenatal exposures in altered brainstem neurochemistry in SIDS.