Incorporating Selenium into Heterocycles and NaturalProducts-From Chemical Properties to Pharmacological Activities
Incorporating Selenium into Heterocycles and NaturalProducts-From Chemical Properties to Pharmacological Activities
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将硒纳入杂环和天然产物——从化学性质到药理活性
DOI：
10.1021/acs.jmedchem.1c01859
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发表时间：
2022-03-24
影响因子：
7.3
通讯作者：
Xu, Hongtao
中科院分区：
文献类型：
--
作者：
Hou, Wei;Xu, Hongtao
含硒（Se）化合物已成为用于治疗一系列疾病的潜在治疗剂。通过巨大的努力，人们已经获得了相当多的知识来了解硒的复杂化学性质和生物活性，特别是在将其掺入生物活性分子之后。从这个角度出发，我们收集了大量的文献证据，总结和批判性地讨论了硒化合物的药理活性和化学性质之间的关系，以及硒与有机分子，特别是生物活性杂环化合物和天然产物的战略结合。我们还提供了有关硒为基础的药物化学和未来研究方向的挑战的观点
Selenium (Se)-containing compounds have emerged as potential therapeutic agents for the treatment of a range of diseases. Through tremendous effort, considerable knowledge has been acquired to understand the complex chemical properties and biological activities of selenium, especially after its incorporation into bioactive molecules. From this perspective, we compiled extensive literature evidence to summarize and critically discuss the relationship between the pharmacological activities and chemical properties of selenium compounds and the strategic incorporation of selenium into organic molecules, especially bioactive heterocycles and natural products. We also provide perspectives regarding the challenges in selenium-based medicinal chemistry and future research directions