Evaluation of iron content in human cerebral cavernous malformation using quantitative susceptibility mapping.
Evaluation of iron content in human cerebral cavernous malformation using quantitative susceptibility mapping.
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DOI：
10.1097/rli.0000000000000043
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发表时间：
2014-07
影响因子：
6.7
通讯作者：
Awad IA
中科院分区：
文献类型：
--
作者：
Tan H;Liu T;Wu Y;Thacker J;Shenkar R;Mikati AG;Shi C;Dykstra C;Wang Y;Prasad PV;Edelman RR;Awad IA
研究和验证定量磁敏感性成像（QSM）用于脑海绵状血管畸形（CCM）病变铁定量。磁共振成像（MRI）研究在幻影和16例患者进行了3 T扫描仪。QSM、磁敏感加权成像（SWI）和R2* 标测图是根据采用三维、多回波和T2* 加权梯度回波序列采集的体内数据重建的。磁化率测量与SWI和R2* 结果相关。此外，从手术切除的CCM病变标本的铁浓度测定使用电感耦合等离子体质谱法和相关的QSM测量。QSM图像表现出良好的图像质量描绘CCM病变在散发性和家族性病例。易感性测量显示与R2* 值正线性相关（总体R2 = 0.99，平均R2 = 0.69; p < 0.01）。已知的富含铁的大脑区域的QSM值与先前的研究和观察者间的一致性密切匹配。在4个切除的人CCM病变标本的18个碎片中，发现QSM与铁幻影浓度之间（0.925，p < 0.01）以及QSM与铁沉积的质谱估计之间（总铁为0.999，铁浓度为0.86; p < 0.01）存在强相关性。通过体模、体内和离体验证研究说明了QSM评价CCM病变中铁沉积的能力。QSM可能是监测CCM疾病活动和治疗反应的潜在生物标志物。
To investigate and validate quantitative susceptibility mapping (QSM) for lesional iron quantification in cerebral cavernous malformations (CCM). Magnetic resonance imaging (MRI) studies were performed in phantoms and 16 patients on a 3T scanner. QSM, susceptibility weighted imaging (SWI), and R2* maps were reconstructed from in vivo data acquired with a three-dimensional, multi-echo, and T2*-weighted gradient echo sequence. Magnetic susceptibility measurements were correlated to SWI and R2* results. In addition, iron concentrations from surgically excised CCM lesion specimens were determined using inductively coupled plasma mass spectrometry and correlated with QSM measurements. The QSM images demonstrated excellent image quality for depicting CCM lesions in both sporadic and familial cases. Susceptibility measurements revealed a positive linear correlation with R2* values (R2 = 0.99 for total, R2 = 0.69 for mean; p < 0.01). QSM values of known iron-rich brain regions matched closely with previous studies and in interobserver consistency. A strong correlation was found between QSM and the concentration of iron phantoms (0.925, p < 0.01), as well as between QSM and mass spectroscopy estimation of iron deposition (0.999 for total iron, 0.86 for iron concentration; p < 0.01) in 18 fragments of 4 excised human CCM lesion specimens. The ability of QSM to evaluate iron deposition in CCM lesions was illustrated via phantom, in vivo and ex vivo validation studies. QSM may be a potential biomarker for monitoring CCM disease activity and response to treatments.