Sclerostin expression and functions beyond the osteocyte.
Sclerostin expression and functions beyond the osteocyte.
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DOI：
10.1016/j.bone.2016.11.024
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发表时间：
2017-03
期刊：
影响因子：
4.1
通讯作者：
Oursler MJ
中科院分区：
文献类型：
--
作者：
Weivoda MM;Youssef SJ;Oursler MJ
硬化素是SOST基因的产物，是骨细胞产生的Wnt信号传导的分泌抑制剂，以调节骨形成。虽然它通常被认为是一种骨细胞特异性蛋白，但SOST表达已在许多其他细胞类型中报道，包括肥大软骨细胞和牙骨质细胞。感兴趣的是，SOST/sclerostin的表达在某些致病条件下改变，包括骨关节炎和风湿性关节疾病，目前还不清楚sclerostin是否起保护作用或sclerostin是否可能介导疾病的发病机制。因此，随着抗sclerostin抗体被开发用于治疗骨质疏松症，重要的是要了解sclerostin在骨形成调控之外的功能。
Sclerostin, the product of the SOST gene, is a secreted inhibitor of Wnt signaling that is produced by osteocytes to regulate bone formation. While it is often considered an osteocyte-specific protein, SOST expression has been reported in numerous other cell types, including hypertrophic chondrocytes and cementocytes. Of interest, SOST/sclerostin expression is altered in certain pathogenic conditions, including osteoarthritis and rheumatic joint disease, and it is unclear whether sclerostin plays a protective role or whether sclerostin may mediate disease pathogenesis. Therefore, as anti-sclerostin antibodies are being developed for the treatment of osteoporosis, it is important to understand the functions of sclerostin beyond the regulation of bone formation.