Is Insulin the Link Between Hypertension and Obesity?
Is Insulin the Link Between Hypertension and Obesity?
复制标题
胰岛素是高血压和肥胖之间的联系吗？
作者：
A. Christlieb;A. Krolewski;J. Warram;J. Soeldner
对195例糖耐量减低患者进行口服葡萄糖耐量试验及血糖、胰岛素测定。根据血压水平将患者分为三组：正常，低于140/90 mm Hg;舒张期高血压，舒张压高于90 mm Hg;收缩期高血压，收缩压高于140，舒张压低于90 mm Hg。各组之间的性别、年龄和血糖水平相似。舒张期高血压患者血清胰岛素水平明显升高（P < 0.01）。校正体重后，这种差异持续存在。这些结果表明循环胰岛素水平和舒张压之间存在因果关系，并支持高胰岛素血症可能是高血压、糖尿病和肥胖聚集的共同联系的概念。
Oral glucose tolerance tests with plasma glucose and insulin determinations were performed on 195 patients with impaired glucose tolerance. Patients were divided into three groups according to blood pressure levels: normal, below 140/90 mm Hg; diastolic hypertension, diastolic pressure above 90 mm Hg; and systolic hypertension, systolic pressure above 140 and diastolic pressure below 90 mm Hg. Sex, age, and glucose levels were similar among the groups. By contrast, serum insulin levels were significantly elevated for the patients with diastolic hypertension (p < 0.01). This difference persisted after correction for body weight. These results suggest a causal relationship between the level of circulating insulin and diastolic blood pressure, and support the concept that hyperinsulinemia may be the common link in the clustering of hypertension, diabetes, and obesity.