Thyrotropin-releasing hormone (TRH) in abstinent alcoholic men.
Thyrotropin-releasing hormone (TRH) in abstinent alcoholic men.
复制标题
戒酒男性的促甲状腺激素释放激素（TRH）。
DOI：
10.1176/ajp.140.9.1145
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
A. Tipermas
中科院分区：
文献类型：
--
作者：
P. Loosen;Wilson Ic;Dew Bw;A. Tipermas
Chronic alcoholics who had been abstinent from alcohol for more than 2 years were evaluated with the thyrotropin-releasing hormone (TRH) test. The findings suggest the following profound disturbances in the hypothalamic-pituitary-thyroid axis: 1) a "euthyroid sick syndrome," evidenced by low levels of triiodothyronine (T3), high levels of reverse T3, and normal levels of thyroxine (T4) (this syndrome implies a decreased 5'-deiodination of T4 to T3 and of reverse T3 to its lesser iodinated metabolites), 2) an increased binding capacity for thyroid hormones, evidenced by a decreased T3-uptake value and an increased level of T4-binding globulin, and 3) thyroid-stimulating hormone (TSH) blunting in 31% of patients. Paradoxically, there was a positive correlation between basal T4 and delta max TSH in subjects with blunted TSH, but baseline TSH levels were reduced in subjects with and without blunted TSH.
